This article reviews the design of a recently published randomized controlled trial (RCT) on immediate vs delayed access to gender-affirming hormones for transgender and gender-diverse (TGD) people and outlines key learning points that clinicians should know about how RCTs can…
Discussions of nonhuman research ethics tend to focus on what we owe nonhuman research subjects in laboratory settings only. But humans make critical decisions about these animals outside the lab, too, during breeding, transportation, and end-of-study protocols. This article reviews…
The Principles of Humane Experimental Technique established what many know today as the “3 R’s – refinement, reduction, and replacement” when it was published in 1959. Since their formulation, these principles have guided decision-making for many about nonhuman animal subjects’…
If we assume that nonhuman animals experience pain or distress, then ethically justifying human-centered research with only nonhuman animals as subjects likely requires that the research’s benefits to humans must, at least, outweigh harms suffered by the nonhuman animals. Yet…
This activity is comprised of five multiple-choice questions based on the content of an AMA Journal of Ethics podcast about why the “three R’s” of nonhuman animal research might not be sufficient to promote good science, ethics, and nonhuman animal…
This case report describes a case of opioid-induced myoclonus.
This case report describes a diagnosis of left ventricular anterior free-wall rupture in a patient given anticoagulant treatment for subacute myocardial infarction.
This JAMA Insights investigates the increased rates of climate change’s related preventable injury and the importance of emergency and disaster preparedness as well as injury and violence prevention.
Importance Advancing precision psychiatry, where treatments are based on an individual’s biology rather than solely their clinical presentation, requires attention to several key attributes for any candidate biomarker. These include test-retest reliability, sensitivity to relevant neurophysiology, cost-effectiveness, and scalability. Unfortunately, these…
Importance Pericarditis accounts for up to 5% of emergency department visits for nonischemic chest pain in North America and Western Europe. With appropriate treatment, 70% to 85% of these patients have a benign course. In acute pericarditis, the development of constrictive…
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