Importance Psychiatry mainly deals with conditions that are mediated by brain function but are not directly attributable to specific brain abnormalities. Given the lack of concrete biological markers, such as laboratory tests or imaging results, the development of diagnostic systems is…
Importance Necrotizing soft tissue infections (NSTIs) are severe life- and limb-threatening infections with high rates of morbidity and mortality. Unfortunately, there has been minimal improvement in outcomes over time. Observations NSTIs are characterized by their heterogeneity in microbiology, risk factors, and anatomical…
This JAMA Clinical Guidelines Synopsis summarizes the 2022 recommendations on evaluation of suspected antibiotic allergies from the American Academy of Allergy, Asthma & Immunology and American College of Allergy, Asthma & Immunology.
A male individual in his 20s presented with a widespread papular eruption starting at age 2 years. What is your diagnosis?
Hosted by AMA’s Firearm Injury Prevention Task Force Injuries and deaths from firearms are a public health crisis. In 2020, firearm injuries became the leading cause of death in children and adolescents in the United States. While this is a…
Importance Over the past 2 decades, systemic therapy for early-stage breast cancer has gradually moved from the adjuvant to the neoadjuvant setting. Administration of systemic therapy before surgery leads to potential improvements in surgical outcomes and allows for the assessment of…
A 13-year-old female individual presented with chronic facial pain and abnormal computed tomography findings and a history of developmental delay, atrial septal defect, cerebral palsy, and pulmonary artery sling. What is your diagnosis?
Importance Kidney disease is common in infants admitted to the neonatal intensive care unit (NICU). Despite the risk of chronic kidney disease (CKD) in infants discharged from the NICU, neither evidence- nor expert-based recommendations exist to guide clinical care after discharge….
Importance While the typical onset of multiple sclerosis (MS) occurs in early adulthood, 2% to 10% of cases initially present prior to age 18 years, and approximately 5% after age 50 years. Guidance on approaches to differential diagnosis in suspected MS…
This case report describes a woman in her mid 30s with diabetes who had been treated with insulin therapy, no history of diabetic ketoacidosis, and normal levels of C-peptide.
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