JAMA Ophthalmology

Bilateral Retinal Vascular Tortuosity and Hemorrhages

A 28-year-old man presented with decreased visual acuity in his right eye for the past 2 weeks. Examination revealed dilated and tortuous veins, Roth spots, and white intraretinal agglomerates. What would you do next?

Immunotherapy for a Choroidal Pigmented Lesion

A 51-year-old male with a a history of BRAF V600 E mutation-positive, superficial spreading-type cutaneous melanoma on the chest with metastasis to a sentinel lymph node had a 4-week history of redness and swelling of the right temporal bulbar conjunctiva…

Episodic Upper Eyelid Edema in an African American Patient

An African American patient in their 60s with a history of monoclonal gammopathy of unknown significance presents to the oculoplastic service for intermittent, bilateral upper eyelid swelling and pain for 2 years. Examination reveals hyperpigmented, spongy eyelid edema with redundant…

Filamentous RPE Hyperplasia in Combined Hamartoma of the Retina and RPE

This case report describes a diagnosis of combined hamartoma of the retina and retinal pigment epithelium (RPE) with filamentous RPE hyperplasia in a female child with a history of amblyopia, myopia, and exotropia of the affected eye.

Fluorescein Angiography of Floating Retinal Veins

This case report describes a diagnosis of floating retinal veins in a patient aged 4 years with a history of stage 2 familial exudative vitreoretinopathy.

Vitreopapillary Traction in Stickler Type IV COL9A1

This case report describes a woman aged 43 years with Stickler syndrome and bilateral vitreopapillary traction who presented with shadows and ghosting of vision in both eyes.

Acute Corneal Edema in a Middle-Aged Patient

A middle-aged patient who had bilateral penetrating keratoplasty 20 years ago for keratoconus presented with pain and blurriness of the right eye for 2 days. Despite prompt corticosteroid therapy, they had no vision improvement and reported occasional pain. What would…

Interventions for Proliferative Vitreoretinopathy

Clinical Question  What is the efficacy of pharmacologic interventions in preventing proliferative vitreoretinopathy? Bottom Line  There is limited high-quality evidence to support currently available pharmacological options for prevention of proliferative vitreoretinopathy.

Interventions for Dry Eye – An Overview of Systematic Reviews

Importance  Dry eye is a common ocular disease that can have substantial morbidity. Systematic reviews provide evidence for dry eye interventions and can be useful for patients, clinicians, and clinical guideline developers. Overviews of reviews use explicit and systematic methods to…