Importance Advances in tumor immunology and vaccine technology are reshaping cancer vaccine development after decades of limited clinical success. More than 2000 immunogenic tumor proteins or antigens have been identified, the types of immune responses required for tumor eradication have…
This case report describes 11.7-T in vivo human brain magnetic resonance imaging (MRI) of the basal ganglia in 2 healthy volunteers.
Importance Traumatic colon and rectal injuries generate wide practice variation across diagnosis, operative strategy, technical conduct, and perioperative care. Management has shifted from mandatory fecal diversion toward selective primary repair and physiology-guided reconstruction, but decision-making remains inconsistent. Objective To develop…
Importance Pseudofolliculitis barbae (PFB) is a chronic inflammatory disease caused by penetration of a shaved, curved hair shaft into the skin. Standardized recommendations for diagnosing and managing PFB are needed. Objective To establish expert consensus recommendations outlining best practices for…
This JAMA Insights discusses the importance of medicolegal evaluations for those seeking asylum and encourages clinicians to complete additional training to conduct these evaluations.
This case report describes a man with enlargement of the lower legs with pink nodules and malodor.
Importance Colorectal cancer is the third most common and deadly cancer among women worldwide. Although ovarian metastases from colon cancer are relatively uncommon, they remain clinically significant due to their association with poor prognosis and the longstanding suspicion that the…
This case report of a 31-year-old woman who underwent Nd:YAG laser vitreolysis for floaters describes the postoperative development of a macular hole and its treatment.
A 34-year-old man with no significant medical history presented with progressive dysphonia, dysphagia, and an infiltrative laryngeal mass that remained nondiagnostic on multiple biopsies. What was the diagnosis?
Importance Patent protection allows pharmaceutical companies to charge high prices for prescription drugs during periods of market exclusivity, and their expiration usually defines when generic competitors can enter the US market. Patents on drug active ingredients are classified as primary…
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