Importance Rheumatoid arthritis (RA) is a chronic autoimmune disease that causes inflammation and destruction of cartilage and adjacent bone and can lead to irreversible disability. Rheumatoid arthritis affects 0.53% of adults worldwide and 0.74% of US adults. Observations Rheumatoid arthritis…
Importance Social media use has grown rapidly, with particularly high adoption among adolescents. These patterns carry both risks, such as problematic use, and potential benefits, such as social connection, creating challenges for policymakers developing regulatory approaches. Objective To synthesize existing…
This case report discusses a clinical diagnosis of Waardenburg syndrome type II in a woman aged 69 years who presented with bilateral iris and choroidal hypopigmentation and hyperpigmentation and a history of congenital deafness, iris heterochromia, and a gray hair…
Importance Leiomyosarcoma is a rare and heterogeneous malignant mesenchymal neoplasm associated with substantial morbidity and mortality. Given recent advances in biologic understanding and the complexity of leiomyosarcoma, a consensus-driven approach is needed to harmonize management and address remaining clinical and…
Importance Advances in the understanding of the pathophysiology of thyroid eye disease (TED) provide an opportunity to use novel, targeted therapeutic agents. However, our capacity to assess the efficacy and indications for the new agents is potentially limited by the…
This JAMA Insights discusses the medical use of psilocybin, particularly for depression treatment, including emerging potential indications, safety, and future use.
Importance The incidence of cognitive decline increases exponentially with age, presenting important implications for professionals in cognitively demanding fields such as medicine. Despite an aging health care workforce, how jurisdictions assess for and address cognitive decline in physicians remains poorly…
Importance Idiopathic normal pressure hydrocephalus (iNPH) is a progressive neurological disorder characterized by cerebral ventricular enlargement that is typically associated with gait impairment and often urinary dysfunction and cognitive decline in older adults. iNPH prevalence is approximately 1% to 4%…
This case report describes a patient in their 70s initially diagnosed with cerebral amyloid angiopathy whose diagnosis was challenged with repeat magnetic resonance imaging, which revealed arterialized left temporal cortical vein with an adjacent venous aneurysm.
Importance The Joint Commission requires hospitals and behavioral health care organizations to identify patients at risk of suicide (National Patient Safety Goal 15.01.01). Risk algorithms and in-person screening for suicide risk show utility in identifying patients at risk of suicidal…
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