Importance The US Food and Drug Administration (FDA) Sentinel Initiative’s Active Risk Identification and Analysis (ARIA) system enables medical product safety surveillance using a large, national distributed network of administrative claims and electronic health record data. As FDA increasingly emphasizes…
A 17-year-old male with a 3-month history of bilateral blurred vision and photophobia presents with placoid lesions in both eyes and further vision loss in the right eye. What would you do next?
Importance Psychedelic drugs possess acute psychoactive effects that can compromise blinding integrity in randomized clinical trials (RCTs). Functional unblinding, when participants or raters correctly identify treatment allocation based on subjective effects, may bias outcomes through expectancy effects, challenging the validity…
Importance Previous research has suggested that intrawound vancomycin powder reduces deep surgical site infections among patients with periarticular tibial fractures at high risk of infection. It is unknown whether the addition of tobramycin powder further decreases infection rates. Objective To…
Importance Advances in targeted therapeutics have made substantial response states in atopic dermatitis (AD) increasingly attainable. However, the field lacks standardized, internationally endorsed definitions of low disease activity (LDA), very low disease activity (vLDA), and remission to benchmark treatment response,…
A man in his 30s presented with a linear atrophic plaque on his forehead that has increased in size over 3 years; biopsy finds loss of sebaceous glands, preserved eccrine glands, and thickened collagen bundles. What is your diagnosis?
A 52-year-old man had 2 days of cough, dyspnea, and fever. Physical examination showed a rash on the trunk and back with clear vesicles on an erythematous base, imaging showed pulmonary infiltrates, and results of laboratory testing were positive for…
This case report describes a woman in her 30s with a 10-year history of systemic lupus erythematosus presented with fever, chest tightness, oliguria, and lower extremity edema.
This case report describes a patient receiving peritoneal dialysis who presented to the emergency department with a fever and elevated procalcitonin levels the day after receiving a COVID-19 vaccine.
This case report describes a 58-year-old man with a 10-day history of left eye redness, proptosis, blurred vision, and left-sided head pressure.
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