Importance Endometrial cancer accounts for 95% of uterine cancers. Uterine cancers are the fourth most common cancer in women in the US, with an estimated 68 270 new cases and 14 450 cancer deaths projected to occur in 2026. The US mortality…
Importance Surgical quality assessment has largely focused on addressing risk-adjusted postoperative outcomes, which neglects quality assessment across the entire perioperative surgical continuum. The Veterans Health Administration (VA) has the unique opportunity to employ a surgical episode framework to measure surgical…
This case report discusses the use of swept-source optical coherence tomography to evaluate the location and morphology of lens lesions.
Importance Colorectal cancer (CRC) risk among older adults with prior adenoma is uncertain. Objective To estimate cumulative CRC risks, non-CRC mortality, and all-cause mortality among adults 75 years of age or older with vs without adenoma at prior colonoscopy (in…
A man in his 70s with a history of hypertension, dyslipidemia, chronic obstructive pulmonary disease, and aortoiliac occlusive disease was admitted with a symptomatic impending rupture of a thoracic aortic aneurysm, followed by reticulate erythematous to violaceous macules that appeared…
This JAMA Clinical Guidelines Synopsis summarizes the American College of Gastroenterologyís 2025 recommendations on management of Crohn disease in adults.
Importance Seasonal or climate variation is increasingly recognized as being associated with the incidence of several acute abdominal conditions, yet its role in diverticulitis remains uncertain. Understanding temporal trends may provide insight into modifiable environmental or behavioral risk factors and…
Importance Preclinical evidence and case reports suggest potential therapeutic benefits of ketogenic diets (KDs) in the treatment of depression, but evidence from well-controlled randomized clinical trials (RCTs) is lacking. Objective To assess the efficacy of a KD compared with a…
Importance Artificial intelligence (AI)–enabled scribes have been proposed to reduce electronic health record (EHR) burden and improve clinician satisfaction. There is limited evidence about their associated results across multiple sites and relative benefits for different clinician groups. Objective To assess…
This Teachable Moment describes how traditional titration protocols for patients with fentanyl use disorder may be inadequate for patients with frequent, high-dose, or high-potency opioid use.
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