This case report describes abdominal clonus diagnosed in a man aged 49 years with a history of a T5 spinal cord injury, kidney dysfunction, and obesity who presented with worsening involuntary movements of the abdomen.
Importance Restless legs syndrome (RLS) is a sleep-related movement disorder that affects approximately 3% of US adults to a clinically significant extent and can cause substantial sleep disturbance. Observations Restless legs syndrome is characterized by an overwhelming urge to move the limbs,…
Importance Glucagon-like peptide-1 (GLP-1) therapies have revolutionized the management of chronic conditions like obesity and diabetes. Consistent with the overlap between feeding and metabolic pathways and those mediating addictive behaviors, growing evidence suggests that GLP-1 therapies may also be beneficial for…
This JAMA Clinical Guidelines Synopsis summarizes the 2024 Canadian Research Initiative in Substance Matters (CRISM) guideline on management of opioid use disorder (OUD).
This case report describes a man in his 30s who was referred for the evaluation of a 3-month destructive process affecting the nail matrix and nail plate of the left thumbnail.
Importance Adjuvant immunotherapy is increasingly integrated into cancer care to reduce recurrence and improve survival. However, its high cost raises critical concerns regarding affordability and economic value across diverse health system contexts. Objective To synthesize published economic evaluations of adjuvant immunotherapy and…
A 36-year-old man with a 4-year history of Crohn disease who was receiving maintenance therapy with infliximab presented with 6 months of progressive left mandibular pain and swelling. What is your diagnosis?
Importance IgA nephropathy (IgAN) is a chronic kidney disease involving deposition of IgA-containing immune complexes in the glomerulus, causing glomerular inflammation and scarring. It is the most common immune-mediated glomerular disease worldwide, and affects an estimated 198 887 to 208 184 persons in…
This case report describes the electrocardiogram findings of a patient in their 60s with lightheadedness and a short episode of numbness.
Importance Acute appendicitis is the most common abdominal surgical emergency worldwide and a leading cause of emergency hospital admissions and operations. Despite its frequency, substantial variability persists in diagnosis and management across patient populations and health care settings. Objective To provide updated,…
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