Extravasation of Iodine Contrast
This case report describes an older man with acute ischemic stroke who developed painful lesions around the intravenous line.
Journal-based
Preexposure Prophylaxis for the Prevention of HIV – Updated Evidence Report and Systematic Review for the US Preventive Services Task Force
Importance A 2019 review for the US Preventive Services Task Force (USPSTF) found oral preexposure prophylaxis (PrEP) associated with decreased HIV infection risk vs placebo or no PrEP in adults at increased HIV acquisition risk. Newer PrEP regimens are available. Objective To…
Preexposure Prophylaxis to Prevent Acquisition of HIV – US Preventive Services Task Force Recommendation Statement
Importance An estimated 1.2 million persons in the US currently have HIV, and more than 760 000 persons have died of complications related to HIV since the first cases were reported in 1981. Although treatable, HIV is not curable and has significant…
Coin-Shaped Opacities in the Stomach
On day 7 after hospital admission, a patient with end-stage kidney disease prescribed sevelamer, hydrocodone-acetaminophen, hydromorphone, and chewable lanthanum tablets developed intermittent apneic episodes, bilateral rhonchi, and responsiveness to verbal commands only with deep painful stimulus; a chest radiograph showed…
Screening for Depression and Suicide Risk in Adults – US Preventive Services Task Force Recommendation Statement
Importance Major depressive disorder (MDD), a common mental disorder in the US, may have substantial impact on the lives of affected individuals. If left untreated, MDD can interfere with daily functioning and can also be associated with an increased risk of…
Prescribing Opioids for Pain
This JAMA Clinical Guidelines Synopsis summarizes the Centers for Disease Control and Prevention’s 2022 clinical practice guideline for prescribing opioids for pain.
Intravenous Vitamin C for Patients Hospitalized With COVID-19 – Two Harmonized Randomized Clinical Trials
Importance The efficacy of vitamin C for hospitalized patients with COVID-19 is uncertain. Objective To determine whether vitamin C improves outcomes for patients with COVID-19. Design, Setting, and Participants Two prospectively harmonized randomized clinical trials enrolled critically ill patients receiving organ support in…
Peripheral Blasts in a Patient Receiving Chemotherapy
An older patient with stage II bladder carcinoma presented with 1 week of fatigue and 2 days of dyspnea on exertion. He was receiving carboplatin/gemcitabine with 6 mg of pegylated G-CSF chemotherapy; his white blood cell count was elevated, hemoglobin…
Evaluation and Treatment of Knee Pain – A Review
Importance Approximately 5% of all primary care visits in adults are related to knee pain. Osteoarthritis (OA), patellofemoral pain, and meniscal tears are among the most common causes of knee pain. Observations Knee OA, affecting an estimated 654 million people worldwide, is…
Red Blood Cell Transfusion- 2023 AABB International Guidelines
Importance Red blood cell transfusion is a common medical intervention with benefits and harms. Objective To provide recommendations for use of red blood cell transfusion in adults and children. Evidence Review Standards for trustworthy guidelines were followed, including using Grading of Recommendations Assessment,…
