Brain Organoids in the Study of Psychiatric Disorders
This article discusses the use of brain organoids in modeling the biological mechanisms of psychiatric disease.
JAMA Psychiatry
Modifying Informed Consent to Help Address Functional Unmasking in Psychedelic Clinical Trials
Importance There is unprecedented clinician, industry, and patient interest in the therapeutic development of psychedelic drugs. This is due to a combination of promising clinical trial results, positive media coverage, and the lack of novel pharmacologic treatments for psychiatric disorders in…
Making Progress in Clinical Trials for Suicide Prevention – A Review
Importance Suicide is a public health crisis, and despite renewed efforts to confront this problem, suicide rates continue to rise in the US. While suicide prevention encompasses a broad array of strategies, treatment development is lagging. Within this realm, clinical trials…
Looking Back, Moving Forward—Reflecting on a Career in Psychiatric Research
The arc of my career has focused on the integration of clinical care, mentoring, and research, leading to meaningful research questions and intervention trials advancing the field. In this Special Communication, I first offer a brief synopsis of my work…
Expectancy Effects, Failure of Blinding Integrity, and Placebo Response in Trials of Treatments for Psychiatric Disorders – A Narrative Review
Importance Expectancy effects are significant confounding factors in psychiatric randomized clinical trials (RCTs), potentially affecting the interpretation of study results. This narrative review is the first, to our knowledge, to explore the relationship between expectancy effects, compromised blinding integrity, and the…
Toward Equitable Interventions in Public Mental Health – A Review
Importance The field of public mental health is evolving to tackle the profound impact of global challenges such as climate change, migration, and health crises. These issues accentuate health and social inequities, necessitating a focus on how to achieve interventions that…
Bringing Imaging Biomarkers Into Clinical Reality in Psychiatry
Importance Advancing precision psychiatry, where treatments are based on an individual’s biology rather than solely their clinical presentation, requires attention to several key attributes for any candidate biomarker. These include test-retest reliability, sensitivity to relevant neurophysiology, cost-effectiveness, and scalability. Unfortunately, these…
Prioritization of Psychopathological Symptoms and Clinical Characterization in Psychiatric Diagnoses – A Narrative Review
Importance Psychiatry mainly deals with conditions that are mediated by brain function but are not directly attributable to specific brain abnormalities. Given the lack of concrete biological markers, such as laboratory tests or imaging results, the development of diagnostic systems is…
Essentials of Informed Consent to Psychedelic Medicine
Importance Interest in administering psychedelic agents as mental health treatment is growing rapidly. As drugmakers invest in developing psychedelic medicines for several psychiatric indications, lawmakers are enacting legal reforms to speed access globally, and health agencies are preparing to approve these…
Parameter Space and Potential for Biomarker Development in 25 Years of fMRI Drug Cue Reactivity – A Systematic Review
Importance In the last 25 years, functional magnetic resonance imaging drug cue reactivity (FDCR) studies have characterized some core aspects in the neurobiology of drug addiction. However, no FDCR-derived biomarkers have been approved for treatment development or clinical adoption. Traversing this…
- « Previous
- 1
- 2
- 3
- Next »
