Importance Preliminary studies suggest heart rate variability biofeedback (HRVB) may reduce craving and negative affect in individuals with substance use disorder (SUD), but few studies have evaluated whether this translates into improved substance use outcomes, and no prior studies have examined…
This article illustrates the assumption of path symmetry in current theories of psychopathology and calls for the development of dynamical systems of mental illness that incorporate asymmetry.
Importance Psilocybin use has surged in the US following decriminalization efforts and promising clinical trial results. Mirroring early cannabis legalization, public access and enthusiasm are outpacing regulatory oversight and scientific understanding, posing potential risks to public health. Objective To review emerging evidence…
This article discusses how autophagic mechanisms mediate neurobiological and behavioral changes in stress-induced neuropsychiatric disorders and depression.
Importance As mental health challenges continue to increase globally, using rigorous surveillance frameworks is essential for delivering nuanced population-level insights and informing evidence-based policy decisions. Objective To develop a standard for using nonprobability and probability-based online panel surveys in psychiatric epidemiological research….
Importance Neuropsychiatric disorders impose a substantial burden on individuals and societies worldwide. Despite significant advances in the understanding of the brain, only a handful of mechanism-based treatments for psychiatric disorders have been discovered and validated in the past 50 years. Observations After…
Importance The potential of tools using artificial intelligence (AI) to address the many challenges in delivery of mental health care has been widely discussed. However, the possible negative consequences of AI for such care have received less attention. Observations Integrating AI with…
Importance Glucagon-like peptide-1 (GLP-1) therapies have revolutionized the management of chronic conditions like obesity and diabetes. Consistent with the overlap between feeding and metabolic pathways and those mediating addictive behaviors, growing evidence suggests that GLP-1 therapies may also be beneficial for…
Importance Experiences of marginalization by gender minority people may predispose them to poorer mental health outcomes than their cisgender peers. Understanding mental health conditions in transgender (trans) and nonbinary people is an essential step in addressing potential inequities in outcome for…
Importance Behavioral variant frontotemporal dementia (bvFTD), the most common subtype of FTD, is a leading form of early-onset dementia worldwide. Accurate and timely diagnosis of bvFTD is frequently delayed due to symptoms overlapping with common psychiatric disorders, and interest has increased…
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