Importance Psychiatric classification faces longstanding challenges, including heterogeneous diagnostic categories, high comorbidity rates, limited interrater reliability, and modest clinical utility. Successive revisions of systems such as the DSM since 1980 have done little to resolve these issues. How to move forward? Observations This narrative…
Importance Adults with severe mental illness (SMI) face a 10- to 20-year reduction in life expectancy, largely due to heightened cardiometabolic diseases. Low levels of physical activity (PA) and prolonged sedentary behavior (SB) are modifiable risk factors that contribute to this…
Importance Major depressive disorder (MDD) is a debilitating neuropsychiatric disease associated with high risk of death by suicide. MDD is heterogeneous, and genome-wide association studies (GWASs) have established that MDD is polygenic, reporting thousands of small-effect variants. There is a significant…
Importance Preliminary studies suggest heart rate variability biofeedback (HRVB) may reduce craving and negative affect in individuals with substance use disorder (SUD), but few studies have evaluated whether this translates into improved substance use outcomes, and no prior studies have examined…
This article illustrates the assumption of path symmetry in current theories of psychopathology and calls for the development of dynamical systems of mental illness that incorporate asymmetry.
Importance Psilocybin use has surged in the US following decriminalization efforts and promising clinical trial results. Mirroring early cannabis legalization, public access and enthusiasm are outpacing regulatory oversight and scientific understanding, posing potential risks to public health. Objective To review emerging evidence…
This article discusses how autophagic mechanisms mediate neurobiological and behavioral changes in stress-induced neuropsychiatric disorders and depression.
Importance As mental health challenges continue to increase globally, using rigorous surveillance frameworks is essential for delivering nuanced population-level insights and informing evidence-based policy decisions. Objective To develop a standard for using nonprobability and probability-based online panel surveys in psychiatric epidemiological research….
Importance Neuropsychiatric disorders impose a substantial burden on individuals and societies worldwide. Despite significant advances in the understanding of the brain, only a handful of mechanism-based treatments for psychiatric disorders have been discovered and validated in the past 50 years. Observations After…
Importance The potential of tools using artificial intelligence (AI) to address the many challenges in delivery of mental health care has been widely discussed. However, the possible negative consequences of AI for such care have received less attention. Observations Integrating AI with…
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