Journal-based CME Course: Cross-Species Framework for Emotional Well-Being and Brain Aging – Lessons From Behavioral Neuroscience

Activity ID

14253

Expires

May 7, 2028

Format Type

Journal-based

CME Credit

Fee

$30

CME Provider: JAMA Psychiatry

Description of CME Course

Importance Emotional well-being (EWB) is an emerging therapeutic target for managing and preventing symptoms associated with Alzheimer disease and related dementias (ADRD). However, more research is needed to establish causal inferences between brain changes, EWB, and behavioral changes observed in typical aging and ADRD.

Observations This article presents a framework for using a cross-species behavioral neuroscience approach to study EWB and brain aging, adopting a well-established biobehavioral model that highlights the reciprocal roles of brain changes, EWB, and ADRD symptoms. First, the challenges and opportunities in this field are reviewed. Then, a practical solution to improve comparability between animal and human studies is proposed.

Conclusions and Relevance The goal is to draw comprehensive parallels and distinctions that could enhance the understanding of the mechanisms linking brain aging, EWB, and ADRD symptomatic disturbances across different species.

Disclaimers

1. This activity is accredited by the American Medical Association.
2. This activity is free to AMA members.

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NOTE: If a Member Board has not deemed this activity for MOC approval as an accredited CME activity, this activity may count toward an ABMS Member Board’s general CME requirement. Please refer directly to your Member Board’s MOC Part II Lifelong Learning and Self-Assessment Program Requirements.

General Information on CME Activity

Educational Objectives

To identify the key insights or developments described in this article

Keywords

Neurology, Geriatrics, Neuroscience, Alzheimer's Disease, Dementia and Cognitive Impairment

Competencies

Medical Knowledge

CME Credit Type

AMA PRA Category 1 Credit

DOI

10.1001/jamapsychiatry.2025.0581