Emulating a Target Trial Using Observational Data
This Guide to Statistics and Methods discusses target trial emulation, including why to use it, limitations of the method, and how to interpret target trial emulation findings.
JAMA Internal Medicine
Patient-Centered Buprenorphine Dosing in the Fentanyl Era
This Teachable Moment discusses initiation, optimization, and long-term use of buprenorphine in man with an opioid use disorder.
What Is a Stepped-Wedge Cluster Randomized Trial?
This Guide to Statistics and Methods describes design, interpretation, and examples of a stepped-wedge cluster randomized trial.
Supervised Exercise Therapy for Peripheral Artery Disease
This Teachable Moment discusses a woman in her 60s with hypertension, hyperlipidemia, coronary artery disease, and smoking history who presented with bilateral, aching leg pain triggered by walking and relieved by rest.
The Harm of Inappropriate Central Line Blood Cultures in Clinical Practice
This case report describes a 57-year-old man with end-stage kidney disease who was receiving hemodialysis through a tunneled central venous catheter and had severe hyperkalemia that prompted admission for emergent hemodialysis.
Electrocardiogram Intricacies in a Patient With Prostate Cancer—The Heart of the Matter
This case report describes the electrocardiagram findings of a patient in their 60s with chest tightness and dyspnea, left ventricular systolic impairment, and elevated troponin I levels.
Guideline-Directed Medical Therapy Intolerance in Heart Failure
This Teachable Moment discusses guideline-directed medical therapy intolerance in a woman in her 80s with heart failure with reduced ejection fraction and transthyretin amyloid cardiomyopathy.
When Dysuria Is More Than Just a Urinary Tract Infection – A Teachable Moment
This Teachable Moment describes a 66-year-old woman with mild dysuria, vulvar discomfort, and recurrent urinary tract infections.
ST-Segment Elevation in the Stress Laboratory
This case report describes a woman in her early 60s who went into cardiac arrest immediately after administration of an echocardiogram contrast agent.
A Clinical Update on MASLD
Metabolic dysfunction–associated steatotic liver disease (MASLD; formerly nonalcoholic fatty liver disease) is a growing cause of chronic liver disease, affecting 25% of the population in the US and 30% of the population globally.1 It is the second leading indication for liver…
