Integrating Diet and Physical Activity When Prescribing GLP-1s—Lifestyle Factors Remain Crucial
This Clinical Insight reviews the lifestyle factors important for patients receiving glucagon-like peptide-1 and dual receptor agonists to manage weight.
JAMA Internal Medicine
Diagnosis and Management of Monoclonal Gammopathy of Undetermined Significance – A Review
Importance Nearly 5% of adults have the precursor malignant condition monoclonal gammopathy of unknown significance (MGUS). Management centers on differentiating MGUS from more serious conditions to determine additional diagnostic testing, monitoring, and potential therapy. Observations MGUS is defined by the absence of…
Benzocaine-Induced Methemoglobinemia After Nasogastric Tube Insertion
This Teachable Moment describes an 87-year-old man who underwent fatal complications from the use of benzocaine spray for nasopharyngeal anesthesia before the insertion of a nasogastric tube.
Emulating a Target Trial Using Observational Data
This Guide to Statistics and Methods discusses target trial emulation, including why to use it, limitations of the method, and how to interpret target trial emulation findings.
Patient-Centered Buprenorphine Dosing in the Fentanyl Era
This Teachable Moment discusses initiation, optimization, and long-term use of buprenorphine in man with an opioid use disorder.
What Is a Stepped-Wedge Cluster Randomized Trial?
This Guide to Statistics and Methods describes design, interpretation, and examples of a stepped-wedge cluster randomized trial.
Supervised Exercise Therapy for Peripheral Artery Disease
This Teachable Moment discusses a woman in her 60s with hypertension, hyperlipidemia, coronary artery disease, and smoking history who presented with bilateral, aching leg pain triggered by walking and relieved by rest.
The Harm of Inappropriate Central Line Blood Cultures in Clinical Practice
This case report describes a 57-year-old man with end-stage kidney disease who was receiving hemodialysis through a tunneled central venous catheter and had severe hyperkalemia that prompted admission for emergent hemodialysis.
Electrocardiogram Intricacies in a Patient With Prostate Cancer—The Heart of the Matter
This case report describes the electrocardiagram findings of a patient in their 60s with chest tightness and dyspnea, left ventricular systolic impairment, and elevated troponin I levels.
Guideline-Directed Medical Therapy Intolerance in Heart Failure
This Teachable Moment discusses guideline-directed medical therapy intolerance in a woman in her 80s with heart failure with reduced ejection fraction and transthyretin amyloid cardiomyopathy.
