Missed Posterior Myocardial Infarction Leading to Free Wall Rupture
This case report describes a patient in her early 60s who presented with substernal chest pain and diaphoresis.
JAMA Internal Medicine
A Case for Early High-Dose ThiamineóMoving From Reaction to Prevention
This Teachable Moment describes a patient in their 60s with severe alcohol use disorder and alcohol-induced cirrhosis complicated by ascites who presented with an altered mental status.
A Distinctive Pattern With Coexisting Malignant Arrhythmias
This case report describes a patient in their 50s with spontaneous chest tightness and palpitations.
Azelastine Nasal Spray for Prevention of SARS-CoV-2 Infections – A Phase 2 Randomized Clinical Trial
Importance Limited pharmaceutical options exist for preexposure prophylaxis of COVID-19 beyond vaccination. Azelastine, an antihistamine nasal spray used for decades to treat allergic rhinitis, has in vitro antiviral activity against respiratory viruses, including SARS-CoV-2. Objective To determine the efficacy and safety of…
Higher-Valent Pneumococcal Conjugate Vaccines—Perspective for 2026
This Clinical Insights describes updated pneumococcal conjugate vaccines and their recommended use in adults.
The Harms of Inappropriate Food-Specific Immunoglobulin E TestingóLess Is More
This Teachable Moment describes a 56-year-old woman with a concern for a food allergy and bilateral leg muscle spasms.
Supporting Shared Decision-Making in Life-Altering Kidney Therapy Decisions for Older Adults – A Review
Importance Older adults represent the fastest-growing population initiating dialysis in the US. For older adults with advanced chronic kidney disease (CKD), initiating dialysis is often the default option presented, as they are often ineligible for kidney transplant. This approach may not…
An Uncommon Cause of Bradycardia Treated With Catheter Ablation
This case report describes a woman in her 50s who presented for evaluation of fatigue and exertional dyspnea.
Active Comparator New User Cohort Studies and Matching
This Guide to Statistics and Methods provides an overview of the active comparator, new user design and the use of propensity score matching.
Implementing Benzodiazepine Deprescribing in the Primary Care Clinic
This Clinical Insight contextualizes benzodiazepine deprescribing guidelines for primary care physicians and high-risk populations.
