JAMA Dermatology

An Isolated Red Plaque on the Anterior Chest

A 6-year-old girl had a slightly sunken red plaque that was observed on the chest, approximately 1.5 cm in diameter, with a smooth surface, associated vascular dilation, well-defined borders, and no scaling or ulceration. What is your diagnosis?

Melanoma-Associated Leukoderma

This case report describes a woman with color change involving only the facial skin and was later found to also have inguinal lymph node and rectal mass.

Indurated Red Nodules and Plaques on the Thigh of a Female Patient

A woman in her 40s with a medical history of complex regional pain syndrome presented to the dermatology department for evaluation of a pruritic recurrent rash on her right anterior thigh. What is your diagnosis?

HutchinsonñGilford Progeria Syndrome

This case report describes a boy younger than 2 years with Hutchinson-Gilford progeria syndrome.

Asymptomatic Yellow-Brown Plaques on the Great Toes

A man in his 30s presented with a 6-month history of asymptomatic yellow-brown plaques on the first digits of his feet that were unresponsive to urea cream and clobetasol treatment. What is your diagnosis?

Alkaptonuria

This case report describes a man in his 50s with progressive blue-gray discoloration of sun-exposed areas, including the nose, cheeks, ears, and hands.

Papular and Vesicular Lesions on the Vulva and Thighs

A woman in her 60s, who had undergone hysterectomy, adnexectomy, and concurrent chemoradiotherapy for cervical cancer 8 years prior, presented with a 2-year history of painful pink vesicular and papular lesions on the vulva and thighs. What is your diagnosis?