Alcohol and Cancer Risk
This JAMA Insights discusses the evidence related to the US Surgeon General’s Advisory on alcohol and cancer risk.
JAMA
Alteplase for Acute Ischemic Stroke at 4.5 to 24 Hours – The HOPE Randomized Clinical Trial
Importance The safety and efficacy of intravenous thrombolytics beyond 4.5 hours after ischemic stroke onset remain inadequately studied. Objective To evaluate the safety and efficacy of intravenous alteplase administered 4.5 to 24 hours after stroke onset in patients with salvageable brain tissue,…
Geroscience – A Translational Review
Importance The incidence of stroke, heart failure, dementia, many cancers, coronary artery disease, and physical disability rise exponentially with age. Geroscience is a relatively new discipline that aims to define and modify aging-related biologic pathways, slow age-related disability, prevent age-related diseases,…
Prostatitis – A Review
Importance Prostatitis is defined as infection, inflammation, or pain of the prostate gland and affects approximately 9.3% of men in their lifetime. Observations Acute bacterial prostatitis consists of a urinary tract infection (UTI) that includes infection of the prostate, typically associated with…
A 34-Year-Old With Recurrent Strokes
A 34-year-old patient with a family history of stroke had right-sided headache, left upper extremity hemiparesis, and left hand numbness; magnetic resonance angiography showed bilateral narrowing of the terminal portion of the intracranial carotid arteries, more severe on the right….
Dalbavancin for Treatment of Staphylococcus aureus Bacteremia
Importance Dalbavancin is a long-acting intravenous lipoglycopeptide that may be effective for treatment of complicated Staphylococcus aureus bacteremia without requiring long-term intravenous access. Objective To evaluate the efficacy and safety of dalbavancin vs standard therapy for completion of treatment of complicated S aureus bacteremia. Design, Setting,…
Measles
This JAMA Insights discusses transmission, clinical presentation, and diagnosis of measles and emphasizes the importance of vaccination to protect those at highest risk for complications from measles, including young children and pregnant individuals.
Reducing Barriers to Mental Health Care for Physicians – An Overview and Strategic Recommendations
Importance Mental health challenges among physicians represent a critical public health issue with profound implications for health care delivery and workforce sustainability. Despite the proven effectiveness of mental health treatment in improving outcomes, most physicians with mental health conditions do not…
Hemorrhoidal Disease – A Review
Importance Hemorrhoidal disease, pathology of the tissue lining of the anal canal, affects approximately 10 million individuals in the US. Hemorrhoidal disease may impair quality of life due to bleeding, pain, anal irritation, and tissue prolapse. Observations Hemorrhoids are classified as internal,…
Stapokibart for Severe Uncontrolled Chronic Rhinosinusitis With Nasal Polyps – The CROWNS-2 Randomized Clinical Trial
Importance Chronic rhinosinusitis with nasal polyps causes severe symptoms and impaired quality of life. Stapokibart is a novel monoclonal antibody that targets interleukin 4Rα. Objective To assess the efficacy and safety of stapokibart as an add-on treatment to intranasal corticosteroids in patients…
