Management of Severe Refractory Asthma
This JAMA Insights explores the management of severe refractory asthma, including medications, access to specialists, and managing environmental triggers.
JAMA
Extracorporeal Life Support in Accidental Hypothermia
This JAMA Insights discusses the definition and classification of accidental hypothermia as well as indications for extracorporeal life support.
Individualized Perioperative Blood Pressure Management in Patients Undergoing Major Abdominal Surgery – The IMPROVE-multi Randomized Clinical Trial
Importance Intraoperative hypotension is associated with organ injury. However, it remains unknown if targeted blood pressure management during surgery can improve clinical outcomes. Objective To evaluate whether individualized vs routine perioperative blood pressure management during major abdominal surgery improves clinical outcomes in…
AI, Health, and Health Care Today and Tomorrow – The JAMA Summit Report on Artificial Intelligence
Importance Artificial intelligence (AI) is changing health and health care on an unprecedented scale. Though the potential benefits are massive, so are the risks. The JAMA Summit on AI discussed how health and health care AI should be developed, evaluated, regulated,…
Microplastics and Human Health
This JAMA Insights discusses rising detection of microplastics in human tissue and the importance of international cooperation to limit plastic pollution.
Painful Hand Swelling With Finger Contractures
A 56-year-old woman with no history of rheumatic disease or hand injury had swelling and tenderness of the bilateral wrists, metacarpophalangeal and proximal interphalangeal joints, nodular palmar tendon thickening, and flexion contractures of all fingers; results of serologic testing for…
Syphilis – A Review
Importance Syphilis is an infectious disease caused by Treponema pallidum, a gram-negative, spirochete bacterium. Worldwide, an estimated 8 million adults aged 18 to 49 years acquired syphilis in 2022. From 2019 to 2023, US syphilis cases increased by 61% overall, with diagnoses…
Semaglutide and Tirzepatide in Patients With Heart Failure With Preserved Ejection Fraction
Importance Heart failure with preserved ejection fraction (HFpEF) is a major cause of hospitalization, often occurring in patients with cardiometabolic comorbidities such as obesity and type 2 diabetes. Although early trials of semaglutide and tirzepatide have shown promising results in improving…
Recurrent Clostridioides difficile Infections
This JAMA Insights discusses the epidemiology, diagnosis, and treatment of recurrent Clostridioides difficile infections.
A Direct-to-Patient Digital Health Program for Lung Cancer Screening – A Randomized Clinical Trial
Importance Screening chest computed tomography (CT) scans reduce lung cancer mortality in high-risk individuals, but less than 20% of eligible individuals are screened in the US. Objective To determine whether a direct-to-patient digital health program increases lung cancer screening. Design, Setting, and…
