A patient with a bioprosthetic aortic valve implanted 6 years prior to presentation had fevers, malaise, and weight loss. Coxiella burnetii titers, erythrocyte sedimentation rate, and levels of C-reactive protein and rheumatoid factor were elevated; transesophageal echocardiography showed a thickened…
This JAMA Insights discusses the most effective management strategies for tricuspid regurgitation, including medications and surgical interventions.
This JAMA Insights discusses medical consequences of and treatment options for methamphetamine use disorder, including harm reduction, behavioral treatment, and pharmacologic treatment.
Importance Hypothyroidism is a disease of thyroid hormone deficiency. The prevalence ranges from 0.3% to 12% worldwide, depending on iodine intake, and it is more common in women and older adults. Untreated hypothyroidism can cause serious health complications such as heart…
Importance When randomized trials are unavailable or not feasible, observational studies can be used to answer causal questions about the comparative effects of interventions by attempting to emulate a hypothetical pragmatic randomized trial (target trial). Published guidance to aid reporting of…
Screen use, the time spent engaging with electronic devices such as mobile phones and tablets, can become addictive when individuals experience difficulty stopping despite attempts to do so, as well as symptoms of withdrawal, tolerance, conflict, and relapse (Box). Adolescence…
This JAMA Insights discusses common viral infections associated with injection drug use, including HIV and hepatitis, as well as strategies for prevention.
This JAMA Insights article explores a variety of current and emerging nutrient-stimulated, hormone-based medications for the treatment of individuals with obesity.
Importance Superficial vein thrombosis (SuVT) is characterized by thrombus in the superficial veins, typically in the lower or upper extremities, and has an estimated annual incidence of 64 to 131 per 100 000 person-years. Approximately 10% of patients with SuVT progress to…
A 2-month-old boy had multiple annular, pink papules and plaques with hyperpigmentation and desquamation on the scalp, palms, and soles; physical examination and ultrasound revealed hepatosplenomegaly, and aspartate and alanine aminotransferase levels were elevated. What is the diagnosis and what…
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