JAMA

Augmented Enteral Protein During Critical Illness – The TARGET Protein Randomized Clinical Trial

Importance  Guidelines recommend augmenting enteral protein during critical illness, but the impact on patient outcomes is uncertain. Objective  To determine whether augmenting enteral protein increases days alive and free from hospitalization. Design, Setting, and Participants  This cluster randomized, crossover, open-label trial recruited critically…

Tipping Point Analysis – Assessing the Potential Impact of Missing Data

This JAMA Guide to Statistics and Methods explains tipping point analysis, which assesses how a range of hypothetical patterns in missing outcome data in a randomized clinical trial (RCT) would affect the study’s conclusions, and examines its use in an…

Adrenal Insufficiency in Adults – A Review

Importance  Adrenal insufficiency is a syndrome of cortisol deficiency and is categorized as primary, secondary, or glucocorticoid induced. Although primary and secondary adrenal insufficiency are rare, affecting less than 279 per 1 million individuals, glucocorticoid-induced adrenal insufficiency is common. Observations  Primary adrenal…

Occupational Heat-Related Illness

This JAMA Insights proposes solutions to help reduce the risk of heat-related illnesses among workers.  

Inhaled Pharmacotherapy for Stable COPD

This JAMA Clinical Guidelines Synopsis summarizes the 2025 Global Strategy for the Diagnosis, Management, and Prevention of COPD.

Diagnosis and Treatment of Type 2 Diabetes in Adults – A Review

Importance  Type 2 diabetes involves progressive loss of insulin secretion from pancreatic β cells in the setting of insulin resistance and manifests clinically as hyperglycemia. Type 2 diabetes accounts for 90% to 95% of all cases of diabetes globally, with estimates…

Screening for Intimate Partner Violence and for Caregiver Abuse of Older or Vulnerable Adults – An Evidence Report and Systematic Review for the US Preventive Services Task Force

Importance  Intimate partner violence (IPV) and caregiver abuse of older or vulnerable adults are common and cause significant morbidity. Objective  To review the evidence on screening and interventions for IPV and caregiver abuse among adults. Data Sources  PubMed, Cochrane Library, and EMBASE through…

Forearm Pain and Stiffness in a 34-Year-Old Woman

A 34-year-old woman had progressive skin tightening over her right elbow and forearm, bilateral forearm pain, difficulty extending her fingers and elbows, and elevated eosinophil count and C-reactive protein level; examination showed a linear depression along a superficial vein when…