Medical Knowledge

Prozone Effect of the AQP4-IgG Test in a Patient With NMOSD

This case report describes a false-negative result of the aquaporin-4ñimmunoglobulin G (AQP4-IgG) test due to the prozone effect in a woman with neuromyelitis optica spectrum disorder (NMOSD).

A Fall Prevention Program Integrated in Primary Health Care for Older People in Rural China – The FAMILY Cluster Randomized Clinical Trial

Importance  With rapidly aging populations globally, there is a lack of evidence on effective fall prevention strategies among community-dwelling older people in resource-constrained areas. Objective  To assess the effectiveness of a fall prevention program integrated in primary health care systems on the…

Cutaneous Melanoma – A Review

Importance  Melanoma, the fifth most common cancer in the US, has increased from 8.8 per 100 000 in 1975 to 28.42 per 100 000 in 2022. Cutaneous melanoma comprises 94% of cases, with 104 960 US cases projected for 2025. Observations  Cutaneous melanoma presents as…

Learning From Error: Applying Root Cause Analysis in Health Care

In health care settings, thorough investigations are vital for identifying design flaws and process errors. This microlesson focuses on root cause analysis (RCA), a type of investigation designed to identify the underlying causes of events. Through case studies and interactive…

Advanced Cardiac Life Support Training

This CME activity offers a series of evidence-based certification courses designed for healthcare professionals, including ACLS, BLS, PALS, CPR, and other emergency care training programs. Each course provides up-to-date guidelines, clinical algorithms, and practical skills needed to recognize, manage, and…

Updates in Primary Immunodeficiency 2026

Primary immunodeficiency (PI) disorders, also called inborn errors of immunity, are a group of nearly 500 disorders characterized by abnormalities in the immune system. These disorders have a relatively rare prevalence, with approximately 1% to 2% of the global population…

12th Annual Mayo Clinic Rheumatology Review for Primary Care 2026

This course provides internists and general practitioners with up-to-date information on rheumatologic disorders and provides a complete general review for rheumatologists, rheumatology fellows and advanced practice providers. From this course, participants gain a better perspective of how to recognize and…