Medical Knowledge

Toward Equitable Interventions in Public Mental Health – A Review

Importance  The field of public mental health is evolving to tackle the profound impact of global challenges such as climate change, migration, and health crises. These issues accentuate health and social inequities, necessitating a focus on how to achieve interventions that…

Aortic Stenosis, Heart Failure, and Aortic Valve Replacement

Importance  Heart failure (HF) and aortic stenosis (AS) frequently coexist, presenting a complex clinical challenge due to their intertwined pathophysiology and associated high morbidity and mortality. Despite numerous advancements in transcatheter and surgical aortic valve replacement (AVR), HF decompensation remains the…

Buprenorphine/Naloxone vs Methadone for the Treatment of Opioid Use Disorder

Importance  Previous studies on the comparative effectiveness between buprenorphine and methadone provided limited evidence on differences in treatment effects across key subgroups and were drawn from populations who use primarily heroin or prescription opioids, although fentanyl use is increasing across North…

Subconjunctival Mass 30 Years After Melanoma Resection

A 70-year-old male is referred for evaluation of a conjunctival mass in the right eye, which has grown slowly over 27 years. Examination reveals a superonasal, multilobulated, pigmented lesion with episcleral feeder vessels and spontaneous vascular pulsations within the intraocular…

Making the Ethical Oversight of All Clinical Trials Fit for Purpose

Importance  With the increase in trials assessing comparative effectiveness of approved products and alternative care strategies, guidance is needed to ensure ethical oversight is fit for purpose for the risks, burdens, and constraints on choice this research presents. Observations  US regulations governing…

Strategies to Help Patients Navigate High Prescription Drug Costs

Importance  In the US, many patients struggle to afford prescription drugs, leading to adverse health outcomes. To improve cost-related medication nonadherence, prescribers and clinical staff must understand how to assist patients in overcoming high prescription drug costs. Observations  We reviewed the benefits…