Medical Knowledge

A Reddish Semitransparent Tumor in an Adolescent Girl

A previously healthy 16-year-old girl presented with a lesion on her right upper arm that initially started as a small cutaneous nodule without obvious triggers and gradually developed and enlarged to form a red-colored tumor with a hard nodule inside….

Focal Dermal Hypoplasia

This case report describes facial atrophic papules with telangiectasias, streaked hypopigmented and hyperpigmented papules on the left side of the trunk and extremities, and soft yellow fat herniations.

Enrollment of Older Patients, Women, and Racial and Ethnic Minority Individuals in Valvular Heart Disease Clinical Trials – A Systematic Review

Importance  Inadequate representation of older patients, women, and racial minority individuals in cardiovascular clinical trials limits both the generalizability of trial findings and inclusivity in access to novel therapies and therapeutic strategies. Objective  To report on temporal trends in the representation of…

Sedentary Behavior and Incident Dementia Among Older Adults

Importance  Sedentary behavior is associated with cardiometabolic disease and mortality, but its association with dementia is unclear. Objective  To investigate whether accelerometer-assessed sedentary behavior is associated with incident dementia. Design, Setting, and Participants  A retrospective study of prospectively collected data from the UK…

Prenatal Intravenous Magnesium at 30-34 Weeks’ Gestation and Neurodevelopmental Outcomes in Offspring – The MAGENTA Randomized Clinical Trial

Importance  Intravenous magnesium sulfate administered to pregnant individuals before birth at less than 30 weeks’ gestation reduces the risk of death and cerebral palsy in their children. The effects at later gestational ages are unclear. Objective  To determine whether administration of magnesium…