Epilepsy in a Patient With Brain Herniation Into the Arachnoid Granulation
This case report describes epilepsy in a 50-year-old patient with brain herniation into the arachnoid granulation.
Medical Knowledge
Alternate Hemibody Hyperkinetic and Hypokinetic Movement Disorders Due to Strategic Lesions in Cerebral Toxoplasmosis
This case report describes a women with a background of HIV presenting with complex involuntary movements with markedly different phenomenology on the right and left side of her body.
A New Framework for Dementia Nomenclature
Importance Nomenclature in the field of neurodegenerative diseases presents a challenging problem. Inconsistent use of terms such as Alzheimer disease and dementia has compromised progress in clinical care, research, and development of therapeutics. Dementia-associated stigma further contributes to inconsistent and imprecise language. The result is…
Harmonizing Definitions for Progression Independent of Relapse Activity in Multiple Sclerosis – A Systematic Review
Importance Emerging evidence suggests that progression independent of relapse activity (PIRA) is a substantial contributor to long-term disability accumulation in relapsing-remitting multiple sclerosis (RRMS). To date, there is no uniform agreed-upon definition of PIRA, limiting the comparability of published studies. Objective To…
Assessing the Clinical Utility of Liquid Biopsies Across 5 Potential Indications From Therapy Selection to Population Screening – A Review
Importance There has been great enthusiasm for the emerging technology of molecular-based tests to detect and quantify tumor DNA circulating in the bloodstream, colloquially known as a liquid biopsy. However, less attention has been given to how their clinical utility depends…
Testing Whether Cancer Screening Saves Lives – Implications for Randomized Clinical Trials of Multicancer Screening
Importance Cancer screening is often promoted as a means to save lives. The question of whether cancer screening truly saves lives is becoming increasingly relevant given the growing enthusiasm for multicancer detection blood tests (ie, liquid biopsies). It is possible in…
A Case of S1Q3T3A Classic Nonspecific Electrocardiogram Finding
This case report describes a patient in their 40s with a history of end-stage kidney disease secondary to hypertension and diabetes who presented with fatigue, cough, weakness, and dyspnea on exertion and was subsequently diagnosed with acute disseminated cryptococcal infection.
A Curious Case of Intermittent Negative Deflections Preceding the QRS Complexes
This case report describes a patient in their 60s who developed apparent abnormal Q waves and severe hypomagnesemia while receiving chemotherapy for metastatic rectal carcinoma.
Ominous Electrocardiogram Changes in a Man With Distal Extremity Weakness
This case report describes a man in his 30s who presented to the emergency department with a sudden onset of distal extremity weakness after waking up 10 hours prior.
Point-of-Care Ultrasonography in Suspected Acute Coronary Syndrome
This case report presents the ECG findings of a patient in their 40s with post-tubercular bronchiectasis who presented with acute exacerbation of dyspnea and no chest pain.
