Importance Early-onset gastrointestinal (GI) cancer is typically defined as GI cancer diagnosed in individuals younger than 50 years. The incidence of early-onset GI cancer is rising globally, and early-onset GI cancers represent the most rapidly increasing early-onset cancer in the US….
This case report describes a 65-year-old man with a mobile filling defect detected in his middle cerebral artery during mechanical thrombectomy.
Importance Ovarian cancer is the eighth most common cause of cancer and cancer death in women worldwide. In 2022, ovarian cancer was diagnosed in approximately 324,398 individuals, and 206 839 died of ovarian cancer worldwide. In 2025, it is estimated that…
Dr Mark Greenawald explores the concept of “autonomy” for physicians, offering practical strategies for physicians and practice leaders to foster greater individual autonomy within health care settings, empowering physicians to make decisions that align with their professional values and patient…
This JAMA Insights discusses evidence about the care of patients with firearm injury, including management of chronic pain, peripheral nerve injury, and lead toxicity from bullet fragments.
Importance Pectus arcuatum is a rare anterior chest wall deformity that is often confused with excavatum, carinatum, or a mixed deformity. A complete understanding of its clinical and physiological basis will improve diagnostic accuracy and allow for standardized management. Objectives To gain…
Importance Diverticulosis is defined by the presence of multiple outpouchings (diverticula) originating from the intestinal lumen. Diverticulitis is defined as inflammation of these diverticula. The annual incidence of diverticulitis in the US is approximately 180 per 100 000 people, resulting in approximately…
Importance Proposed US National Institutes of Health (NIH) funding cuts under the second Trump administration have raised concerns about their implications. As a key sponsor of foundational research and workforce training, the NIH plays a vital role in biomedical innovation. Understanding…
Importance A patent foramen ovale (PFO), an opening between the right and left atria during normal fetal development that fails to close after birth, is present in approximately 25% of all adults. Paradoxical embolism, a venous thromboembolism that travels to the…
This JAMA Insights explores optimal strategies for managing the adverse effects associated with incretin-based medications for obesity, including semaglutide and tirzepatide.
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