Prescribing Opioids for Pain
This JAMA Clinical Guidelines Synopsis summarizes the Centers for Disease Control and Prevention’s 2022 clinical practice guideline for prescribing opioids for pain.
ABMS Lifelong Learning CME Activity
Abdominal Pain and Hypotension in a 70-Year-Old Woman
A 70-year-old woman with hypertension, atrial fibrillation, congestive heart failure, and gallstones had 3 days of nausea, vomiting, and abdominal pain. Abdominal computed tomography showed a thickened gallbladder wall with intraluminal air adherent to the duodenum and a gallstone in…
Abdominal Pain and Petechial Rash in a 95-Year-Old Farmer
A 95-year-old farmer taking prednisolone for bullous pemphigoid had 24 hours of abdominal pain, 2 weeks of diarrhea, and 3 months of intermittent abdominal bloating and anorexia. Evaluation showed purpuric macules and small thumbprint-like patches on her upper abdomen and…
Creation and Adoption of Large Language Models in Medicine
Importance There is increased interest in and potential benefits from using large language models (LLMs) in medicine. However, by simply wondering how the LLMs and the applications powered by them will reshape medicine instead of getting actively involved, the agency in…
Patents and Regulatory Exclusivities on GLP-1 Receptor Agonists
Importance Glucagon-like peptide 1 (GLP-1) receptor agonists were first approved for the treatment of type 2 diabetes in 2005. Demand for these drugs has increased rapidly in recent years, as indications have expanded, but they remain expensive. Objective To analyze how manufacturers…
Cervical Cancer Screening – A Review
Importance Each year in the US, approximately 100 000 people are treated for cervical precancer, 14 000 people are diagnosed with cervical cancer, and 4000 die of cervical cancer. Observations Essentially all cervical cancers worldwide are caused by persistent infections with one of 13…
Screening for Latent Tuberculosis Infection in Adults – Updated Evidence Report and Systematic Review for the US Preventive Services Task Force
Importance Latent tuberculosis infection (LTBI) can progress to active tuberculosis disease, causing morbidity and mortality. Objective To review the evidence on benefits and harms of screening for and treatment of LTBI in adults to inform the US Preventive Services Task Force (USPSTF)….
Screening for Latent Tuberculosis Infection in Adults – US Preventive Services Task Force Recommendation Statement
Importance In the US, tuberculosis remains an important preventable disease, including active tuberculosis, which may be infectious, and latent tuberculosis infection (LTBI), which is asymptomatic and not infectious but can later progress to active disease. The precise prevalence rate of LTBI…
Diagnosis and Management of Pituitary Adenomas – A Review
Importance Pituitary adenomas are neoplasms of the pituitary adenohypophyseal cell lineage and include functioning tumors, characterized by the secretion of pituitary hormones, and nonfunctioning tumors. Clinically evident pituitary adenomas occur in approximately 1 in 1100 persons. Observations Pituitary adenomas are classified as…
Intravenous Vitamin C for Patients Hospitalized With COVID-19 – Two Harmonized Randomized Clinical Trials
Importance The efficacy of vitamin C for hospitalized patients with COVID-19 is uncertain. Objective To determine whether vitamin C improves outcomes for patients with COVID-19. Design, Setting, and Participants Two prospectively harmonized randomized clinical trials enrolled critically ill patients receiving organ support in…
