Accounting for Competing Risks in Clinical Research
This JAMA Guide to Statistics and Methods article discusses accounting for competing risks in clinical research.
ABMS Lifelong Learning CME Activity
Clinical Practice Guideline for Red Blood Cell Transfusion Thresholds in Very Preterm Neonates
Importance Red blood cell (RBC) transfusion is a common medical intervention to treat anemia in very preterm neonates; however, best transfusion practices, such as thresholds, remain uncertain. Objective To develop recommendations for clinicians on the use of RBC transfusions in very preterm…
International Consensus on Standard Outcome Measures for Neurodevelopmental Disorders – A Consensus Statement
Importance The use of evidence-based standardized outcome measures is increasingly recognized as key to guiding clinical decision-making in mental health. Implementation of these measures into clinical practice has been hampered by lack of clarity on what to measure and how to…
Low-Dose Corticosteroids for Critically Ill Adults With Severe Pulmonary Infections – A Review
Importance Severe pulmonary infections, including COVID-19, community-acquired pneumonia, influenza, and Pneumocystis pneumonia, are a leading cause of death among adults worldwide. Pulmonary infections in critically ill patients may cause septic shock, acute respiratory distress syndrome, or both, which are associated with mortality rates…
Management of Depression in Adults – A Review
Importance Approximately 9% of US adults experience major depression each year, with a lifetime prevalence of approximately 17% for men and 30% for women. Observations Major depression is defined by depressed mood, loss of interest in activities, and associated psychological and somatic…
Readability of Patient Education Materials in Head and Neck Cancer – A Systematic Review
Importance Patient education materials (PEMs) can promote patient engagement, satisfaction, and treatment adherence. The American Medical Association recommends that PEMs be developed for a sixth-grade or lower reading level. Health literacy (HL) refers to an individual’s ability to seek, understand, and…
Interventions to Prevent Falls in Older Adults – Updated Evidence Report and Systematic Review for the US Preventive Services Task Force
Importance Falls are the most common cause of injury-related morbidity and mortality in older adults. Objective To systematically review evidence on the effectiveness and harms of fall prevention interventions in community-dwelling older adults. Data Sources MEDLINE, Cumulative Index for Nursing and Allied Health…
Interventions to Prevent Falls in Community-Dwelling Older Adults – US Preventive Services Task Force Recommendation Statement
Importance Falls are the leading cause of injury-related morbidity and mortality among older adults in the US. In 2018, 27.5% of community-dwelling adults 65 years or older reported at least 1 fall in the past year and 10.2% reported a fall-related…
Developing an Ethics and Policy Framework for Psychedelic Clinical Care: A Consensus Statement
Importance As government agencies around the globe contemplate approval of the first psychedelic medicines, many questions remain about their ethical integration into mainstream medical practice. Objective To identify key ethics and policy issues related to the eventual integration of psychedelic therapies into…
A Case of Gastric Thickening and a Large Ovarian Mass
A 35-year-old female patient with hypothyroidism and Ehler-Danlos syndrome presents with fatigue, abdominal distension, and dyspnea. What is your diagnosis?
