Maculopathy in a 52-Year-Old Patient With Diabetes
A 52-year-old woman with severe nonproliferative diabetic retinopathy had decreased vision and macular edema in both eyes that was not responding to treatment. What would you do next?
ABMS Lifelong Learning CME Activity
Fever, Rash, and Shortness of Breath in a 69-Year-Old
A 69-year-old had fever, fatigue, rash, right periorbital swelling, and shortness of breath. Chest computed tomography revealed numerous small, bilateral pulmonary nodules; laboratory testing revealed mean corpuscular volume, 96.1 fL; hemoglobin level, 12.4 mg/dL; and leukopenia. What is the diagnosis…
Central Retinal Artery Occlusion With Cilioretinal Artery Sparing
This case report describes a diagnosis of central retinal artery occlusion in a patient in their early 30s who presented with decreased vision in the left eye for 1 week.
Follow-Up of Bilateral Iridoschisis in a Patient With Alport Syndrome
This case report discusses the long-term follow-up of a patient with bilateral iridoschisis and Alport syndrome.
Resolution of Crystalline Retinopathy After Kidney Transplant for Hyperoxaluria
This case report discusses the evolution of crystalline retinopathy secondary to systemic hyperoxalosis after kidney transplant for hyperoxaluria was performed.
Posterior Segment Changes in Gaucher Disease
This case report discusses posterior segment characteristics in a patient aged 24 years with low vision and a history of Gaucher disease.
RNA Interference With Zilebesiran for Mild to Moderate Hypertension – The KARDIA-1 Randomized Clinical Trial
Importance Angiotensinogen is the most upstream precursor of the renin–angiotensin–aldosterone system, a key pathway in blood pressure (BP) regulation. Zilebesiran, an investigational RNA interference therapeutic, targets hepatic angiotensinogen synthesis. Objective To evaluate antihypertensive efficacy and safety of different zilebesiran dosing regimens. Design,…
Diagnosis and Management of Paroxysmal Supraventricular Tachycardia
Importance Paroxysmal supraventricular tachycardia (PSVT), defined as tachyarrhythmias that originate from or conduct through the atria or atrioventricular node with abrupt onset, affects 168 to 332 per 100 000 individuals. Untreated PSVT is associated with adverse outcomes including high symptom burden and…
Interventions for Optimization of Guideline-Directed Medical Therapy – A Systematic Review
Importance Implementation of guideline-directed medical therapy (GDMT) in real-world practice remains suboptimal. It is unclear which interventions are most effective at addressing current barriers to GDMT in patients with heart failure with reduced ejection fraction (HFrEF). Objective To perform a systematic review…
Decentralized Clinical Trials as a New Paradigm of Trial Delivery to Improve Equity of Access
Importance The need to maintain clinical trial recruitment during the COVID-19 pandemic has precipitated the rapid uptake of digital health for the conduct of clinical trials. Different terms are used in different jurisdictions and clinical contexts, including digital trials, networked trials,…
