Peripheral Nerve Blocks for Hip Fractures
This JAMA Insights explores the use of different types of peripheral nerve blocks as an opioid-sparing pain strategy in the treatment of adults with hip fractures.
Journal-based
Sonographic Demonstration of Myopathy in Mycosis Fungoides
This case report describes a diagnosis of muscle infiltration of mycosis fungoides in a female aged 36 years with initial disease manifesting as pigmented skin patches.
Autosomal Dominant Polycystic Kidney Disease – A Review
Importance Autosomal dominant polycystic kidney disease (ADPKD) is characterized by progressive development of kidney cysts and is the most common inherited kidney disorder worldwide. ADPKD accounts for 5% to 10% of kidney failure in the US and Europe, and its prevalence…
Late-Onset Diffuse Xanthomas in an Adult Man
A man in his 60s presented to the hospital with fever, joint pain, and second-degree atrioventricular block. Physical examination revealed diffuse xanthomata, most prominent in the periorbital region. What is your diagnosis?
Two Brothers With 1 Diagnosis
Two brothers, aged 69 and 76 years, were independently referred in the same week for evaluation of a right olfactory cleft tumor that had been progressively developing over several years. Computed tomography demonstrated bilateral masses causing widening of the olfactory…
Immunotherapy Strategies After Immune Checkpoint Inhibitor Exposure in Renal Cell Carcinoma – A Review
Importance Immune checkpoint inhibitors have transformed the treatment landscape for metastatic renal cell carcinoma; however, the failure of first-line therapeutic strategies remains a considerable challenge. Currently, clinicians face various issues, such as managing cases in patients who progress during treatment or…
Iron Deficiency in Adults – A Review
Importance Absolute iron deficiency, defined as low iron stores with or without anemia, affects approximately 2 billion people worldwide and 14% of adults in the US. Iron-deficiency anemia, defined as low hemoglobin due to low iron stores, affects approximately 1.2 billion…
Small Cell Lung Cancer – A Review
Importance Small cell lung cancer (SCLC) is a high-grade neuroendocrine carcinoma with an incidence of 4.7 cases per 100 000 individuals in 2021 in the US and a 5-year overall survival of 12% to 30%. Observations Cigarette smoking is the primary risk factor…
Why Does the History of Circadian Rhythms Matter for Sleep Today?
A paradigm shift in circadian science is underway, exposing ethical tensions from a legacy of pervasive neglect of circadian disorders. This article canvasses ethical questions about stigma, justice, and accommodation that should be formally recognized to reconceive circadian care. Responding…
When Should Pharmacological Interventions for Insomnia Be Recommended?
This commentary on a case describes how social determinants of health also contribute to insomnia and then suggests how to balance risks and benefits of different strategies for managing chronic insomnia. Behaviorally induced insufficient sleep syndrome can exacerbate morning side…
