This Guide to Statistics and Methods provides an overview of the win ratio method for analyzing composite end points in randomized clinical trials, including its benefits and limitations.
A neonate presents with a 1-day history of 15 discrete 2- to 10-mm tense and flaccid yellow vesicles and bullae on the chest, arms, and legs as well as subtle flexural erythema but is otherwise well appearing. What is your…
Importance Urinary tract infection (UTI) is common in ambulatory care settings and the primary reason for antibiotic prescribing. Despite several guidelines focused on the type and duration of antibiotics prescribed for treating UTI, there is limited outpatient guidance on how to…
Importance Antimicrobial resistance (AMR) poses an urgent global health challenge, undermining treatment efficacy and threatening patient safety. Antimicrobial stewardship (AMS) programs are recognized as essential interventions to optimize antibiotic use, but implementation has often been fragmented and underresourced. The Republic of…
This case report discusses a diagnosis of peripheral arteriolar sclerosis and nonperfusion in the left eye of a male patient in his 20s after a contusion injury and subsequent treatment for traumatic iritis and ocular hypertension.
Of all infectious disease events, pandemics could result in significant human depopulation in this Anthropocene epoch or even in the next few centuries. Existential factors that exacerbate pandemic risk include global warming, overpopulation, habitat loss, permafrost thawing, geopolitical conflict, and…
Most physicians do not see, or learn to see, nuclear war threat mitigation as within the scope of their professional duties. This commentary on a case argues there are 2 reasons why physicians, in particular, should draw on their unique…
This commentary on a case builds on recent literature on climate change, health, and human extinction to argue in favor of a new clinical specialty: extinction medicine. If based on precise application of scientific findings about species extinction, disaster prevention…
This article draws a parallel between ethical reasons why people alive today have obligations to members of future generations and ethical reasons why physicians have obligations, besides helping improve patients’ quality of life, to help some patients confront their own…
Is there an important ethical difference between a global catastrophe that causes human extinction and one that does not? This commentary on a case introduces 3 approachesóequivalence, further-loss, and pro-extinctionistóin responding to this question. In particular, focus is placed on…
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