Diabetes and Chronic Kidney Disease
This JAMA Insights discusses the evaluation and treatment of chronic kidney disease in patients with type 1 and type 2 diabetes.
Journal-based
Bilateral Acute Optic Neuropathy in a Teenaged Girl
A 14-year old girl presents with sudden painless vision decline in the left eye for 5 days and reports constant fatigue, occasional dizziness, mild pain in the lower limbs, and intermittent claudication over the past 12 months with no history…
Molecular Testing for the World Health Organization Classification of Central Nervous System Tumors – A Review
Importance Molecular techniques, including next-generation sequencing, genomic copy number profiling, fusion transcript detection, and genomic DNA methylation arrays, are now indispensable tools for the workup of central nervous system (CNS) tumors. Yet there remains a great deal of heterogeneity in using…
How Should the Use of Opioids Be Regulated to Motivate Better Clinical Practice?
This article describes historical and political reasons for and devastating consequences of US opioid prescribing policy since the 1990s, which has restricted opioid prescribing for pain less than for treating opioid use disorder (OUD) treatment. This article considers merits and…
What Would Equitable Harm Reduction Look Like?
Structural determinants of health frameworks must express anti-racism to be effective, but racial and ethnic inequities are widely documented, even in harm reduction programs that focus on person-centered interventions. Harm reduction strategies should express social justice and health equity, resist…
How Should Risks and Benefits of Short-Acting Opioids Be Evaluated in the Care of Inpatients With OUD?
Severe opioid withdrawal, risk of patient-initiated discharge, and some inpatients’ use of unregulated substances prompt clinical and ethical questions considered in this commentary on a case. Short-acting opioids can be used to manage inpatients’ pain and opioid use disorder (OUD)…
How Should Harm Reduction Be Included in Care Continua for Patients With Opioid Use Disorder?
Practices and interventions that aim to slow progression or reduce negative consequences of substance use are harm reduction strategies. Often described as a form of tertiary prevention, harm reduction is key to caring well for people who use drugs. Evidence-based…
Why Evidence Generation Should Matter to Payers and How They Can Help
Importance The US leads the world in bringing new medical products to market, but the ability to generate evidence to inform clinical practice in postmarket settings needs improvement. Although a diverse group of stakeholders is working to improve postmarket evidence generation,…
How Should Harm Reduction Strategies Differ for Adolescents and Adults?
Overall rates of opioid use are low in adolescents; however, recent increases in mortality from overdose in adolescents have outpaced increases in the general population. This article highlights the importance of expanding evidence-based treatment for adolescent opioid use, especially medication,…
Steroid-Responsive Myorhythmia in Pectoralis Muscles
This case report describes a patient experiencing involuntary contractions in his right pectoralis muscles with anti-Tr antibodies in his serum, which is characteristic of myorhythmia.
