Importance Genetic ancestry may complement biological, behavioral, and clinical factors in understanding colorectal cancer (CRC) disparities; yet, ancestry-informed analyses in CRC remain limited. Objective To characterize associations of genetic ancestry with CRC burden, age at diagnosis, and age-specific risk, and…
This nonrandomized clinical trial assesses the safety and efficacy of darolutamide, with or without concomitant lipid-modifying agents (LMAs), in treating nonmetastatic castration-resistant prostate cancer.
Importance Patients with breast cancer (BC) may have long-term fatigue after treatment, which is associated with reduced quality of life. Objective To identify cardiac, psychological, and cancer treatment factors associated with fatigue before and 24 months after BC treatment. Design,…
Importance A comprehensive review of chest tube management was developed to help clinicians better understand the different types of chest tubes, their indications, and key management principles to optimize patient outcomes. With the increasing use of small-bore, “pigtail” catheters in…
Importance The terms neurodivergence and neurodiversity are increasingly used across mental health and broader clinical literature, as well as in clinical practice, clinical service commissioning, and policy contexts, despite their lack of clinical and diagnostic specificity. Objective To quantitively map…
Importance Smoking is the strongest modifiable risk factor for peripheral arterial disease (PAD), yet evidence on how postdiagnosis smoking behavior changes affect clinical outcomes remains limited. Objective To evaluate the association among smoking cessation, reduction, and continuation after PAD diagnosis…
Importance Black women are disproportionately susceptible to developing heart failure and display more severe morbidity and mortality compared with White women. Factors contributing to excess heart failure risk among Black women remain incompletely understood. Objective To characterize the associations of…
Importance Evidence on the association of excess adiposity with colorectal cancer (CRC) prognosis is conflicting, with some studies reporting better survival in patients with elevated body mass index (BMI)—often referred to as the obesity paradox. Objective To investigate to what…
A 54-year-old woman presents with subacute exertional dyspnea after heavy lifting and a history of chronic repetitive upper-limb strain from caregiving. What would you do next?
This JAMA Insights discusses various aspects of primary aldosteronism, such as its epidemiology, diagnosis and screening, and treatment, including effective medication management.
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