This case report discusses a patient with vertebral pseudoaneurysm that spontaneously ruptured and led to vertebro-vertebral arteriovenous fistula requiring endovascular therapy.
Importance Older adults represent the fastest-growing population initiating dialysis in the US. For older adults with advanced chronic kidney disease (CKD), initiating dialysis is often the default option presented, as they are often ineligible for kidney transplant. This approach may not…
This article illustrates the assumption of path symmetry in current theories of psychopathology and calls for the development of dynamical systems of mental illness that incorporate asymmetry.
A man in his 60s who had a kidney transplant was taking mycophenolate mofetil, tacrolimus, and prednisone presented with painless lesions on the left upper extremity. What is your diagnosis?
Importance The effect of sodium bicarbonate infusion on outcome in patients with severe metabolic acidemia and moderate to severe acute kidney injury is unknown. Objective To determine whether sodium bicarbonate infusion is associated with day 90 all-cause mortality in patients with severe…
Importance The optimal strategy for hemodynamic resuscitation in early septic shock remains uncertain. Objective To determine the effect of a personalized hemodynamic resuscitation protocol targeting capillary refill time (CRT-PHR) on a hierarchical composite outcome of mortality, duration of vital support, and length…
Importance The optimal strategy for hemodynamic resuscitation in early septic shock remains uncertain. Objective To determine the effect of a personalized hemodynamic resuscitation protocol targeting capillary refill time (CRT-PHR) on a hierarchical composite outcome of mortality, duration of vital support, and length…
Importance Acute dysfunction of vital organs is the hallmark of critical illness. The Sequential Organ Failure Assessment (SOFA) score, the most widely adopted approach to describe organ dysfunction, has not been updated in 30 years and therefore may not appropriately capture…
Importance The Sequential Organ Failure Assessment (SOFA) score was published in 1996 to describe organ dysfunction in critically ill adult patients in a readily quantifiable and sequential manner. Considerable changes have occurred over the last 3 decades in the use of…
Clinical Question Which topical anti-inflammatory treatments are most effective and safe for managing atopic dermatitis? Bottom Line In a network meta-analyses, very potent/potent topical corticosteroids; tacrolimus, 0.1%; and topical Janus kinase inhibitors were among the most effective treatments for short-term control of…
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