Updating Treatment Goals for Schizophrenia
This article discusses research providing renewed reasons to revisit the utility of glutamatergic drugs for treating schizophrenia.
Journal-based
Generalized Linear Keratotic Papules in a Man in His 30s
A man in his 30s presented with a 5-year history of generalized keratotic papules and plaques accompanied by pruritus. Physical examination revealed numerous dark-red keratotic papules on the trunk and extremities as well as seborrheic dermatitislike erythematous scaly patches on…
Referrals to a Novel Health Care Equity Consult Service
The US Centers for Disease Control and Prevention (CDC) define health equity as “the state in which everyone has a fair and just opportunity to attain their highest level of health.” Achieving this, according to the CDC, requires sustained efforts…
Geyserlike OCT Sign in Transthyretin Amyloidosis
This case report discusses a diagnosis of transthyretin amyloidosis after an unusual finding on optical coherence tomography (OCT) in a woman aged 52 years with dense vitreous opacities.
Adult Male Hypogonadism – A Review
Male hypogonadism is a clinical syndrome of signs and symptoms of testosterone deficiency and consistently low morning serum testosterone concentrations. The prevalence of hypogonadism due to hypothalamus, pituitary, or testes pathology is less than 1%, and the prevalence due to…
Circulating Tumor DNA in Early Breast Cancer – A Review
Circulating tumor DNA (ctDNA) has emerged as a noninvasive biomarker with the potential to detect minimal residual disease (MRD), monitor treatment response, and identify recurrence (eg, molecular relapse) earlier than conventional clinical or imaging approaches. Although ctDNA-based MRD assays have…
Diffuse Pruritic Maculopapular Rash With Pitted Necrosis
A previously healthy woman in her 30s presented with a diffuse maculopapular rash, most prominently on her legs, with pitted necrotic spots, black eschar, and serous fluid weeping with diffuse edema. Histopathology showed areas with abnormal aggregates composed almost entirely…
Pancreatic Panniculitis in a Patient With Lung Cancer
This case report describes a woman in her 50s with metastatic lung adenocarcinoma who presented with a 4-week history of severe arthralgias and painful nodules on her skin.
Hearing Aids for Adults With Mild to Moderate Hearing Loss
This JAMA Insights discusses hearing aids for adults with mild to moderate hearing loss, including hearing aid function and limitations and prescription vs over-the-counter hearing aid devices.
Strategies for Establishing Clinical-Decision Thresholds in Psychiatry – A Review
Importance Nearly all psychopathology is inherently continuous, but both clinical practice and research often require categorical decisions (eg, treat or wait, pay for treatment or decline, enroll in study or not); therefore, thresholds are applied to continuous phenomena to guide…
