Heat and Pregnancy
This JAMA Insights discusses current evidence about risks to the health of pregnant individuals from ambient heat (hot weather, high indoor temperatures, and occupational exposures) and how these risks can be managed.
Journal-based
Recommendations for the Deprescribing of Psychotropic Medications – A Consensus Statement From the American Society of Clinical Psychopharmacology Task Force
Importance There is a need for greater recognition of clinical psychopharmacology endpoints, including instances where specific psychotropic medications may become unnecessary, redundant, contradictory, or otherwise inappropriate and therefore merit deprescribing. Objective To address circumstances warranting psychotropic medication deprescribing. Evidence Review The American Society…
Surgeon Compensation Models – A Systematic Review
Importance Surgeon compensation models influence physician productivity, care quality, and engagement in nonclinical activities. Information on compensation plans across surgical specialties and settings is often difficult to obtain. Objective To describe surgeon compensation models in the US, differentiate models by practice setting,…
Brain and Blood Biomarkers of Major Depressive Disorder – A Systematic Review
Importance Major depressive disorder (MDD) is a debilitating neuropsychiatric disease associated with high risk of death by suicide. MDD is heterogeneous, and genome-wide association studies (GWASs) have established that MDD is polygenic, reporting thousands of small-effect variants. There is a significant…
Worldwide Radiation Dose in Coronary Artery Disease Diagnostic Imaging
Importance In recent decades, there has been marked worldwide growth in diagnostic testing for coronary artery disease (CAD), with several common imaging modalities exposing patients to ionizing radiation. Objective To examine worldwide radiation doses for patients undergoing noninvasive CAD diagnostic testing. Design,…
Purpuric Edematous Papules in a Man With Prostate Cancer
A man in his 60s undergoing radiotherapy for prostate cancer presented to the dermatology clinic with a 1-week history of a tender, pruritic rash to the trunk and extremities. What is your diagnosis?
CONSORTñChildren and Adolescents (CONSORT-C) 2026 Extension Statement – Enhancing the Reporting and Impact of Pediatric Randomized Trials
Importance Randomized controlled trials (RCTs) in children and adolescents provide evidence for patients, families, researchers, clinicians, regulators, funders, policymakers, and other interest holders to inform decisions about health care interventions and improve outcomes for young patients and their families. To critically…
SPIRITñChildren and Adolescents (SPIRIT-C) 2026 Extension Statement – Enhancing the Reporting and Usefulness of Pediatric Randomized Trial Protocols
Importance Key information is often omitted from pediatric randomized controlled trial (RCT) protocols, including details on dose adjustments of interventions based on age, body surface area, or weight; developmental appropriateness of trial outcome measures and processes; or strategies to minimize participants’…
Does This Patient Have Volume Overload? – The Rational Clinical Examination
Importance Accurate assessment of intravascular volume facilitates management decisions about fluid management in patients with volume overload. Objective To identify the most accurate clinical examination, radiographic, and laboratory findings for assessing volume overload in nonintubated patients. Data Sources and Study Selection MEDLINE was…
HIV During Pregnancy and Infant Feeding
This JAMA Insights discusses evidence-based updates to guidelines surrounding taking antiretroviral drugs during pregnancy and infant feeding for individuals with HIV.
