Importance Rising rates of early-onset cancer have generated substantial media coverage and public concern. In response, early-onset cancer has become a federal research priority, and clinical guidelines have shifted to recommend earlier screening for some cancers. Yet, it remains unclear whether…
Importance Approximately 1.5 million adults in the US use supplemental oxygen annually in the outpatient setting. However, many do not receive delivery systems that adequately meet their needs, and few receive education about devices or how to maintain independence. This Review…
This case report describes a patient in his late 60s who presented to the emergency department with a 3-month history of recurrent spontaneous chest tightness, palpitations, and syncope.
This work discusses nonhormonal treatment of menopausal vasomotor symptoms.
Importance Undocumented immigrants represent a disproportionate share of uninsured individuals in the US, owing to federal restrictions that limit access to affordable health care coverage. Emergency Medicaid (EM) and other state-sponsored programs offer mechanisms for receiving necessary medical care, but their…
This Clinical Insights discusses factors clinicians should consider when prescribing denosumab among postmenopausal women with osteoporosis.
This case report describes a 91-year-old woman who presented with dyspnea and fatigue and no history of structural heart disease.
This clinical insight discusses the diagnosis and management of adverse effects of antiamyloid therapies and what medications require consideration or avoidance.
This Guide to Statistics and Methods provides an overview of the covariate-constrained randomization design, which can achieve improved control over large imbalances across study arms at the cluster level over simpler methods of randomization.
This Clinical Insights describes the process for initiating feminizing gender-affirmative hormone therapy for transgender women or nonbinary people.
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