Denosumab and Fracture Prevention in Primary Care Practice
This Clinical Insights discusses factors clinicians should consider when prescribing denosumab among postmenopausal women with osteoporosis.
JAMA Internal Medicine
Atrioventricular Block With Abnormal P Wave
This case report describes a 91-year-old woman who presented with dyspnea and fatigue and no history of structural heart disease.
New Frontier, New Challenges—Recognizing and Managing Adverse Effects of Antiamyloid Therapies
This clinical insight discusses the diagnosis and management of adverse effects of antiamyloid therapies and what medications require consideration or avoidance.
Covariate-Constrained Randomization
This Guide to Statistics and Methods provides an overview of the covariate-constrained randomization design, which can achieve improved control over large imbalances across study arms at the cluster level over simpler methods of randomization.
Gender-Affirming Feminizing Hormone Therapy
This Clinical Insights describes the process for initiating feminizing gender-affirmative hormone therapy for transgender women or nonbinary people.
Continuous Glucose Monitor Use—Avoiding Overuse
This case report describes a patient in their 30s with hypertension, anxiety, depression, chronic tremulousness, nausea, vomiting, headache, and mental fog.
An Unusual Cause of Atrioventricular Block
This case report describes a man in his 60s who presented with a 3-day history of low-grade, intermittent fever, myalgia, and headache, along with episodes of blurred vision and recurrent syncope.
Integrating Diet and Physical Activity When Prescribing GLP-1s—Lifestyle Factors Remain Crucial
This Clinical Insight reviews the lifestyle factors important for patients receiving glucagon-like peptide-1 and dual receptor agonists to manage weight.
Diagnosis and Management of Monoclonal Gammopathy of Undetermined Significance – A Review
Importance Nearly 5% of adults have the precursor malignant condition monoclonal gammopathy of unknown significance (MGUS). Management centers on differentiating MGUS from more serious conditions to determine additional diagnostic testing, monitoring, and potential therapy. Observations MGUS is defined by the absence of…
Benzocaine-Induced Methemoglobinemia After Nasogastric Tube Insertion
This Teachable Moment describes an 87-year-old man who underwent fatal complications from the use of benzocaine spray for nasopharyngeal anesthesia before the insertion of a nasogastric tube.
