JAMA Dermatology

Recurring Papules and Nodules on the Vulva

A woman in her 40s presents with intermittent tender papules and nodules localized to the medial surface of her labia majora and labia minora that have purulent drainage and flares. What is your diagnosis?

Congenital Erythropoietic Porphyria

This case report describes thickened facial skin, microstomia, hypertrichosis, loss of facial features, gum hyperpigmentation, and erythrodontia, as well as severe and destructive photodistributed scarring, with loss of nails, resorption of the distal phalanges, and joint contractures.

An Isolated Red Plaque on the Anterior Chest

A 6-year-old girl had a slightly sunken red plaque that was observed on the chest, approximately 1.5 cm in diameter, with a smooth surface, associated vascular dilation, well-defined borders, and no scaling or ulceration. What is your diagnosis?

Melanoma-Associated Leukoderma

This case report describes a woman with color change involving only the facial skin and was later found to also have inguinal lymph node and rectal mass.

Indurated Red Nodules and Plaques on the Thigh of a Female Patient

A woman in her 40s with a medical history of complex regional pain syndrome presented to the dermatology department for evaluation of a pruritic recurrent rash on her right anterior thigh. What is your diagnosis?

HutchinsonñGilford Progeria Syndrome

This case report describes a boy younger than 2 years with Hutchinson-Gilford progeria syndrome.

Asymptomatic Yellow-Brown Plaques on the Great Toes

A man in his 30s presented with a 6-month history of asymptomatic yellow-brown plaques on the first digits of his feet that were unresponsive to urea cream and clobetasol treatment. What is your diagnosis?

Alkaptonuria

This case report describes a man in his 50s with progressive blue-gray discoloration of sun-exposed areas, including the nose, cheeks, ears, and hands.