Cleveland Clinic

Updates in Primary Immunodeficiency 2026

Primary immunodeficiency (PI) disorders, also called inborn errors of immunity, are a group of nearly 500 disorders characterized by abnormalities in the immune system. These disorders have a relatively rare prevalence, with approximately 1% to 2% of the global population…

Updates in Primary Immunodeficiency 2025

Early diagnosis and appropriate management are crucial for improving the quality of life and prognosis for those with IEI. Advances in genetic research and therapies continue to improve outcomes for many patients with these disorders. However, IEI can be challenging…