Importance Alopecia areata (AA) has a high prevalence worldwide and causes considerable morbidity in patients. Patient-reported outcomes (PROs) have become an important component of clinical outcome assessment. The quality of existing AA-specific PRO measures (PROMs) has not been evaluated to date….
A man in his 40s presents with a progressively enlarging yellow-red plaque on the chest with multiple central yellow papules, open comedones, and telangiectasia. What is your diagnosis?
This case report describes a light pink plaque underneath an atrophied and broken nail plate that was surrounded by depigmentation.
Importance Traditional risk factors, enhancing factors, and risk scores help clinicians assess atherosclerotic cardiovascular disease (ASCVD) risk for primary prevention. The latest cholesterol guidelines suggest measuring coronary artery calcium (CAC) score by computed tomography (CT) in those at intermediate risk when…
A 69-year-old woman developed a nodule in her left eye and reported bilateral eye fatigue, burning, and irritation. The patient had ulcerative colitis, type 2 diabetes, gastroesophageal reflux disease, hypertension, and glaucoma in her right eye. What is your diagnosis?
Importance Eating disorders are characterized by disturbances in eating behavior and occur worldwide, with a lifetime prevalence of 2% to 5%. They are more common among females than males and may be associated with medical and psychiatric complications, impaired functioning, and…
Importance For decades, the 3 therapeutic pillars for head and neck squamous cell carcinoma (HNSCC) have been radiation therapy, chemotherapy, and surgery. In recent years, a fourth pillar, immunotherapy, has shifted the existing paradigm of oncologic care by improving survival outcomes….
Importance Hemoglobin disorders are a considerable public health issue with more than 500 000 affected infants born annually worldwide. First introduced in the 1970s, newborn screening (NBS) for sickle cell disease (SCD) was included in the Recommended Uniform Screening Panel (RUSP) in…
This JAMA Insights discusses the need to fully assimilate evidence from observed and projected effects of climate change on health and invest in developing and implementing effective health protection from preventable climate-sensitive conditions.
This Guide to Statistics and Methods describes design, interpretation, and examples of a stepped-wedge cluster randomized trial.
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