Central Retinal Artery Revascularization Promptly After Tenecteplase
This case report discusses a diagnosis of central retinal artery occlusion and visual prognosis after management with intravenous tenecteplase.
Medical Knowledge
Acute Transient Cataract Associated With 5-Fluorouracil
This case report discusses a diagnosis of transient cataract in the setting of 5-fluorouracil injection to treat a fibrotic trabeculectomy bleb.
Buprenorphine/Naloxone vs Methadone for the Treatment of Opioid Use Disorder
Importance Previous studies on the comparative effectiveness between buprenorphine and methadone provided limited evidence on differences in treatment effects across key subgroups and were drawn from populations who use primarily heroin or prescription opioids, although fentanyl use is increasing across North…
Subconjunctival Mass 30 Years After Melanoma Resection
A 70-year-old male is referred for evaluation of a conjunctival mass in the right eye, which has grown slowly over 27 years. Examination reveals a superonasal, multilobulated, pigmented lesion with episcleral feeder vessels and spontaneous vascular pulsations within the intraocular…
Making the Ethical Oversight of All Clinical Trials Fit for Purpose
Importance With the increase in trials assessing comparative effectiveness of approved products and alternative care strategies, guidance is needed to ensure ethical oversight is fit for purpose for the risks, burdens, and constraints on choice this research presents. Observations US regulations governing…
The Harm of Inappropriate Central Line Blood Cultures in Clinical Practice
This case report describes a 57-year-old man with end-stage kidney disease who was receiving hemodialysis through a tunneled central venous catheter and had severe hyperkalemia that prompted admission for emergent hemodialysis.
Strategies to Help Patients Navigate High Prescription Drug Costs
Importance In the US, many patients struggle to afford prescription drugs, leading to adverse health outcomes. To improve cost-related medication nonadherence, prescribers and clinical staff must understand how to assist patients in overcoming high prescription drug costs. Observations We reviewed the benefits…
A 9-Year-Old Child With a Large Thoracic Mass
A healthy 9-year-old had 10 days of nonproductive cough without fever, wheeze, chest pain, or abdominal pain but with diminished breath sounds in the right lower lung field. Results of laboratory testing were unremarkable; computed tomography revealed a fat-density mass…
Prevention of Anal Cancer in High-Risk Individuals
This JAMA Insights examines the treatment and rising prevalence of anal cancer in the US in high-risk groups, including people with HIV and immunosuppression associated with solid organ transplant.
Monilethrix
This case report describes sparse, unruly, fragile, and easily breakable hair, with patchy alopecia with diffuse follicular papules throughout the scalp as well as short hair with an alternation of darker elliptical nodes, with paler nonmedullated paler internodes giving a…
