Medical Knowledge

Purpuric Edematous Papules in a Man With Prostate Cancer

A man in his 60s undergoing radiotherapy for prostate cancer presented to the dermatology clinic with a 1-week history of a tender, pruritic rash to the trunk and extremities. What is your diagnosis?

AMA STEPSFORWARD – Strengthening Behavioral Health in Native Communities

Delivering effective behavioral and mental health care in American Indian and Alaska Native communities requires more than clinical expertise, it demands culturally safe, structurally competent team-based approaches. In this AMA STEPS ForwardÆ podcast, Dr Aaron Wernham, CEO of the Montana…

CONSORTñChildren and Adolescents (CONSORT-C) 2026 Extension Statement – Enhancing the Reporting and Impact of Pediatric Randomized Trials

Importance  Randomized controlled trials (RCTs) in children and adolescents provide evidence for patients, families, researchers, clinicians, regulators, funders, policymakers, and other interest holders to inform decisions about health care interventions and improve outcomes for young patients and their families. To critically…

SPIRITñChildren and Adolescents (SPIRIT-C) 2026 Extension Statement – Enhancing the Reporting and Usefulness of Pediatric Randomized Trial Protocols

Importance  Key information is often omitted from pediatric randomized controlled trial (RCT) protocols, including details on dose adjustments of interventions based on age, body surface area, or weight; developmental appropriateness of trial outcome measures and processes; or strategies to minimize participants’…

Does This Patient Have Volume Overload? – The Rational Clinical Examination

Importance  Accurate assessment of intravascular volume facilitates management decisions about fluid management in patients with volume overload. Objective  To identify the most accurate clinical examination, radiographic, and laboratory findings for assessing volume overload in nonintubated patients. Data Sources and Study Selection  MEDLINE was…

HIV During Pregnancy and Infant Feeding

This JAMA Insights discusses evidence-based updates to guidelines surrounding taking antiretroviral drugs during pregnancy and infant feeding for individuals with HIV.

Ultra-Widefield OCTA in Leukemic Optic Infiltration

This case report discusses the detailed visualization using optical coherence tomography angiography (OCTA) of vascular abnormalities over the optic disc in the setting of B-cell lymphoblastic leukemia.

Pertussis Infection in Adults

This JAMA Insights discusses the epidemiology, transmission, and risk factors for pertussis, also referred to as whooping cough, in adults.

Subcorneal Pustular Dermatosis

This case report describes a pruritic rash on the trunk and erythematous patches with numerous flaccid, half-half pustules that contained clear and purulent fluid.