Medical Knowledge

Cost-Effectiveness of Adjuvant Immunotherapy in Cancer Treatments – A Systematic Review

Importance  Adjuvant immunotherapy is increasingly integrated into cancer care to reduce recurrence and improve survival. However, its high cost raises critical concerns regarding affordability and economic value across diverse health system contexts. Objective  To synthesize published economic evaluations of adjuvant immunotherapy and…

Progressive Left Mandibular Swelling in a Young Man

A 36-year-old man with a 4-year history of Crohn disease who was receiving maintenance therapy with infliximab presented with 6 months of progressive left mandibular pain and swelling. What is your diagnosis?

IgA Nephropathy in Adults – A Review

Importance  IgA nephropathy (IgAN) is a chronic kidney disease involving deposition of IgA-containing immune complexes in the glomerulus, causing glomerular inflammation and scarring. It is the most common immune-mediated glomerular disease worldwide, and affects an estimated 198 887 to 208 184 persons in…

A Malignant Premature Atrial Contraction

This case report describes the electrocardiogram findings of a patient in their 60s with lightheadedness and a short episode of numbness.

Diagnosis and Treatment of Acute Appendicitis – 2025 Edition of the World Society of Emergency Surgery Jerusalem Guidelines

Importance  Acute appendicitis is the most common abdominal surgical emergency worldwide and a leading cause of emergency hospital admissions and operations. Despite its frequency, substantial variability persists in diagnosis and management across patient populations and health care settings. Objective  To provide updated,…

FMA 2026 Annual Meeting

For the FMA’s 2026 Annual Meeting, three CME tracks have been planned to support physicians in accomplishing the following goals:1. Successfully navigate Florida’s medical landscape; 2. Comply with specific state requirements (screening and making appropriate referrals for domestic violence, improved…

MSToronto2026

MSToronto2026—the 10th Joint Meeting of the Americas Committee for Treatment and Research in Multiple Sclerosis (ACTRIMS) and the European Committee for Treatment and Research in Multiple Sclerosis (ECTRIMS)—is designed to address significant clinical and practice gaps in the diagnosis, management,…

ECHO – Diabetes Care for Whole – Person Health – Spring 2026

The overall goal of ECHO programming is to build new care capacity at the community level. This ECHO will build the capacity of primary clinicians and teams to effectively manage type 2 diabetes and its complications.

ECHO – Foundations of Gender Affirming Care – Spring 2026

The purpose of this 12-session ECHO program is to build the capacity of primary care teams to provide gender-affirming care. ECHO is a tele-mentoring program that uses videoconferencing technology to combine brief expert presentations with interactive and practical case presentations…