Importance There are gaps in the understanding of the clinical actionability of cardiovascular biomarkers for risk stratification during cardiotoxic chemotherapy. Objectives To gain insights into an N-terminal pro–B-type natriuretic peptide (NT-proBNP)–guided approach for cardioprotection in patients with breast cancer or lymphoma treated…
Importance Fibromuscular dysplasia (FMD) is found in 6 to 14% of patients with spontaneous cervical artery dissection (SCEAD) and may be associated with recurrent SCEAD. Objective To evaluate the correlates of FMD in patients with SCEAD and to determine whether FMD is…
Importance Age-related hearing loss is a potentially modifiable risk factor for cognitive impairment and dementia. Objective To investigate the association of hearing loss with brain structure changes, cognitive function, and incident dementia. Design, Setting, and Participants This cohort study included Framingham Heart Study…
Importance There are disparities in blood pressure (BP) levels by race in the US. Objective To estimate the number of cardiovascular disease (CVD) events and deaths that could be prevented among non-Hispanic Black adults by achieving the same mean systolic BP (SBP)…
Importance Early treatment choice in relapsing-remitting multiple sclerosis (RRMS) is prognostically crucial, yet robust comparative data on cladribine vs sphingosine-1-phosphate receptor modulators (S1PRMs) in treatment-naive patients with RRMS are limited. Objective To compare the clinical effectiveness of cladribine vs S1PRMs in treatment-naive…
Importance Patients with gastroparesis who do not respond to medical therapy may require surgical intervention, typically involving pyloroplasty (PP) alone or with implantation of a gastric electrical stimulation (GES) device. Objective To investigate the outcomes of combining PP with GES in medication-refractory…
Importance Sodium-glucose cotransporter-2 inhibitors have emerged as important therapeutic options for heart failure (HF). However, their comparative clinical effectiveness remains uncertain. Objective To compare the outcomes associated with dapagliflozin and empagliflozin use in patients diagnosed with HF. Design, Setting, and Participants This cohort…
Importance Although pharmacovigilance signals and a strong pathophysiological rationale have suggested a potential risk of arterial dissections or aneurysms associated with angiogenesis inhibitors, this association deserves to be further investigated through clinical practice evidence studies. Objective To evaluate the association between exposure…
Importance Cognitive impairment and glycemic control have a bidirectional association. Understanding the impact of continuous glucose monitoring (CGM) vs self-monitoring of blood glucose (SMBG) is important for treating older adults with Alzheimer disease and related dementias (ADRD) and diabetes that is…
Importance Physician burnout and retention problems are threatening workforce stability and patient care. Objective To compare physician well-being in multiple European countries and the US to inform physician well-being interventions and evaluate whether modifiable aspects of hospital care environments are associated with…
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