Spontaneous Intracranial Hypotension Due to Cerebrospinal Fluid Rhinorrhea
This case report describes an 8-year-old girl who presented with cerebrospinal fluid rhinorrhea, brain sagging, and orthostatic headaches.
Medical Knowledge
Denosumab and Fracture Prevention in Primary Care Practice
This Clinical Insights discusses factors clinicians should consider when prescribing denosumab among postmenopausal women with osteoporosis.
AMA STEPSFORWARD – One Doctor’s Search for Humanity in Medicine
Dr Jessi Gold, inaugural chief wellness officer for the University of Tennessee (UT) System, associate professor of psychiatry at the University of Tennessee Health Science Center (UTHSC), practicing outpatient psychiatrist, and author of the book, How Do You Feel?: One…
Alkaptonuria
This case report describes a man in his 50s with progressive blue-gray discoloration of sun-exposed areas, including the nose, cheeks, ears, and hands.
Dry EEG—From Laboratory to Living Room
This article discusses the potential applications of dry electroencephalography (EEG) and its advantages over traditional wet EEG.
Add-On Treatment With Zilebesiran for Inadequately Controlled Hypertension – The KARDIA-2 Randomized Clinical Trial
Importance In prior monotherapy studies of patients with hypertension, single subcutaneous doses of zilebesiran, an investigational RNA interference therapeutic, reduced serum angiotensinogen levels and systolic blood pressure (SBP) at 3 and 6 months. Objective To evaluate the efficacy and safety of zilebesiran…
Uveitis in Adults – A Review
Importance Uveitis is characterized by inflammation of the uvea—the middle portion of the eye composed of the iris, ciliary body, and choroid—causing eye redness, pain, photophobia, floaters, and blurred vision. Untreated uveitis may cause cataracts, glaucoma, macular edema, retinal detachment, optic…
Tracheobronchial Replacement – A Systematic Review
Importance Tracheobronchial replacement remains a surgical and biological challenge despite several decades of experimental and clinical research. Objective To compile a comprehensive state-of-the-science review examining the current indications, techniques, and outcomes of tracheobronchial replacement in human patients. Evidence Review A systematic review of…
Oral Mass in an Infant
A 39-week-old female infant had a large oral mass at delivery and had difficulty feeding without notable respiratory distress. What is your diagnosis?
A Woman With Headache, Fatigue, and Aphasia
A woman with no significant medical history had 3 days of headache, fatigue, and expressive aphasia; laboratory testing showed microangiopathic hemolytic anemia, increasing schistocytes on serial blood smears, diminished ADAMTS13 activity, and a high inhibitor titer. What is the diagnosis…
