Importance There is a lack of randomized clinical trial (RCT) data to guide many routine decisions in the care of children hospitalized for common conditions. A first step in addressing the shortage of RCTs for this population is to identify the…
Importance Metastatic hormone-sensitive prostate cancer is currently an incurable disease. Despite a high response rate to androgen-deprivation therapy, most cases progress to castration-resistant disease, the terminal phase. This review provides a summary of the most recent evidence for current and emerging…
Importance The discovery of the anti-GQ1b antibody has expanded the nosology of classic Miller Fisher syndrome to include Bickerstaff brainstem encephalitis, Guillain-Barré syndrome with ophthalmoplegia, and acute ophthalmoplegia without ataxia, which have been brought under the umbrella term anti-GQ1b antibody syndrome. It…
Importance Generalized pustular psoriasis (GPP) lacks internationally accepted definitions and diagnostic criteria, impeding timely diagnosis and treatment and hindering cross-regional clinical and epidemiological study comparisons. Objective To develop an international consensus definition and diagnostic criteria for GPP using the modified Delphi method….
Clinical Question What is the efficacy of pharmacologic interventions in preventing proliferative vitreoretinopathy? Bottom Line There is limited high-quality evidence to support currently available pharmacological options for prevention of proliferative vitreoretinopathy.
Importance Identification of individuals at high risk for atherosclerotic cardiovascular disease within the population is important to inform primary prevention strategies. Objective To evaluate the prognostic value of routinely available cardiovascular biomarkers when added to established risk factors. Design, Setting, and Participants Individual-level…
One in three pregnant patients run the risk of experiencing uterine tachysystole (UT) during labor augmentation or induction with oxytocin. Reducing UT diagnosis-to-treatment time can avert adverse patient outcomes and decrease the risk of an obstetric malpractice claim. This two-part…
One in three pregnant patients run the risk of experiencing uterine tachysystole (UT) during labor augmentation or induction with oxytocin. Reducing UT diagnosis-to-treatment time can avert adverse patient outcomes and decrease the risk of an obstetric malpractice claim. This two-part…
Researchers have identified more than 100 biases that can interfere with diagnostic reasoning. These biases can sway practitioners’ thinking during both intuitive and deliberative cognitive processes. This activity discusses biases and offers strategies to reduce their detrimental impacts.
Fetal malpresentation is defined as a fetus presenting at birth in a non-vertex presentation as either occiput transverse (OT) or occiput posterior (OP). This condition occurs 15% to 25% at term and 5% to 12% at birth, frequently increases risk…
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