Medical Knowledge

Cheating the Rules of Admission With “Observation”

When physicians admit patients to a hospital, their decisions about where—and to whose professional stewardship and services—those patients belong are influenced by federal policies, of which many clinicians are not aware. The distinction between observation and admission has clinical and…

Neonatal Survival After Serial Amnioinfusions for Bilateral Renal Agenesis – The Renal Anhydramnios Fetal Therapy Trial

Importance  Early anhydramnios during pregnancy, resulting from fetal bilateral renal agenesis, causes lethal pulmonary hypoplasia in neonates. Restoring amniotic fluid via serial amnioinfusions may promote lung development, enabling survival. Objective  To assess neonatal outcomes of serial amnioinfusions initiated before 26 weeks’ gestation…

Reporting of Factorial Randomized Trials – Extension of the CONSORT 2010 Statement

Importance  Transparent reporting of randomized trials is essential to facilitate critical appraisal and interpretation of results. Factorial trials, in which 2 or more interventions are assessed in the same set of participants, have unique methodological considerations. However, reporting of factorial trials…

Syndromic Pattern Recognition in Infection Prevention and Control

Ensuring the health and safety of health care professionals and patients from transmissible diseases is paramount to a robust health care system. Quick identification of potential infections and the implementation of effective infection prevention and control measures are key to…

Progressive Cheek Swelling in an Older Woman

An 87-year-old woman presents with sudden-onset worsening right facial swelling and pain and generalized maxillary alveolar hyperplasia. What is your diagnosis?

APOL1-Mediated Kidney Disease

This JAMA Insights reviews the origin of APOL1 high-risk genetic variants, defines APOL1-mediated kidney disease, and discusses recommendations for screening and management.

Lower Gastrointestinal Hemorrhage

This JAMA Clinical Guidelines Synopsis summarizes the 2023 American College of Gastroenterology guidelines on management of patients with acute lower gastrointestinal bleeding.

Message From an Automated External Defibrillator

This case report describes a man in his 80s who received shock from an automated external defibrillator that registered 3 types of tachycardia.

Arteriovenous Access for Hemodialysis – A Review

Importance  Hemodialysis requires reliable vascular access to the patient’s blood circulation, such as an arteriovenous access in the form of an autogenous arteriovenous fistula or nonautogenous arteriovenous graft. This Review addresses key issues associated with the construction and maintenance of hemodialysis…