Importance Head and neck cancer, which arises in the lining or mucosa of the upper aerodigestive tract, specifically the oral cavity, oropharynx, larynx, hypopharynx, and paranasal sinuses, is the seventh most common cancer worldwide. In 2024, approximately 71 110 individuals in the…
Importance Primary care provides a broad service range, including preventive screenings and chronic disease care. Busy clinicians frequently select which health care processes to address per visit based on time or perceived disease impact, especially for patients with multimorbidity. Little evidence…
Importance Primary mitral regurgitation (MR) is a prevalent valvular lesion. Current American College of Cardiology/American Heart Association guidelines include class I recommendations for intervention for severe primary MR at the onset of symptoms, significant left ventricular (LV) enlargement (end-systolic dimension ≥40…
This Guide to Statistics and Methods provides an overview of using observational data and reinforcement learning strategies to develop dynamic treatment regimes for patients who are critically ill.
A woman in her 30s presented with a chronic, painful, nonhealing ulcer on her fifth finger that developed after trauma 1 year earlier. What is your diagnosis?
Importance Molecular analyses of biospecimens collected from study participants are essential for identifying biomarkers that can tailor treatments to specific subsets of patients who are most likely to benefit. Sharing of data and biospecimens from clinical trials enables personalized, patient-centric use…
This case report discusses presumed progression of maculopathy secondary to pentosan polysulfate sodium prescribed for daily use over a period of 4 years in a patient with a history of interstitial cystitis.
This case report discusses a diagnosis of mucosa-associated lymphoid tissue (MALT) in a patient in their 60s with a 17-year history of a left eyelid and periorbital mass.
This case report discusses a diagnosis of optic nerve colobomatous cyst diagnosed in an infant who presented with left exotropia and no accompanying systemic abnormalities.
This case report discusses a diagnosis of reticular epithelial corneal edema in a male patient aged 57 years who presented with a sudden decrease in vision in his right eye, which was receiving treatment with netarsudil for neovascular glaucoma.
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