Importance Since 2018, a movement has emerged to define Alzheimer disease (AD) as a purely biological entity based on biomarker findings. The recent revision of the Alzheimer’s Association (AA) criteria for AD furthers this direction. However, concerns about a purely biological…
This activity is comprised of five multiple-choice questions based on the content of an AMA Journal of Ethics podcast about therapeutic music and peace in health care. The featured guests are Daniel Levitin, PhD, neuroscientist, cognitive psychologist, and author of…
This Teachable Moment describes a 66-year-old woman with mild dysuria, vulvar discomfort, and recurrent urinary tract infections.
Importance Chimeric antigen receptor (CAR) T cells are T lymphocytes that are genetically engineered to express a synthetic receptor that recognizes a tumor cell surface antigen and causes the T cell to kill the tumor cell. CAR T treatments improve overall…
Importance Traditional approaches to practice guidelines frequently result in dissociation between strength of recommendation and quality of evidence. Objective To create a clinical guideline for the diagnosis and management of urinary tract infections that addresses the gap between the evidence and recommendation…
A 30-year-old nulliparous woman with obesity and history of migraines and depression had 1 month of daily headaches, transient bilateral visual blurring, persistent vision loss in the temporal region of one eye, pulsatile tinnitus, and mild bilateral papilledema. What is…
This case report describes nontender, soft, and mobile tissue proliferations involving the anterior, lateral, and posterior neck spaces and diffuse, nonencapsulated soft tissue masses that were widely distributed across superficial and deep fascial spaces.
Importance Inferior vena cava filters (IVCFs) are commonly used to prevent pulmonary embolism in selected clinical scenarios, despite limited evidence to support their use. Current recommendations from professional societies and the US Food and Drug Administration endorse timely IVCF retrieval when…
This JAMA Insights discusses the important role that interpreters play in facilitating communication between patients with limited English-language proficiency and their health care team and provides steps that can be taken to improve communication with remote interpreters for patients.
A 46-year-old woman is referred for a second opinion with recent onset of suspected seizures and imbalance. Fundus examination revealed bilateral discrete perifoveal circular areas of atrophy. What would you do next?
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