Importance Cell and gene therapies are revolutionizing the treatment landscape for children and adults with rare diseases and can be life-changing for patients and their families. Successful implementation of these new therapies into clinical practice depends on their accessibility and affordability,…
Importance Fragility fractures result in significant morbidity. Objective To review evidence on osteoporosis screening to inform the US Preventive Services Task Force. Data Sources PubMed, Embase, Cochrane Library, and trial registries through January 9, 2024; references, experts, and literature surveillance through July 31,…
Importance Osteoporotic fractures are associated with psychological distress, subsequent fractures, loss of independence, reduced ability to perform activities of daily living, and death. Objective The US Preventive Services Task Force (USPSTF) commissioned a systematic review to evaluate the evidence on the benefits…
Importance The emergency department (ED) offers an opportunity to initiate palliative care for older adults with serious, life-limiting illness. Objective To assess the effect of a multicomponent intervention to initiate palliative care in the ED on hospital admission, subsequent health care use,…
This JAMA Guide to Statistics and Methods article discusses clinical trials using factorial designs in which participants receive several randomized interventions simultaneously to allow efficient evaluation of multiple therapies and their combinations.
This Surgical Innovation describes a new method to repair large or recurrent paraesophageal hernias.
Importance Integration of molecular biomarker information into systemic therapy has become standard practice in breast cancer care. However, its implementation in guiding radiotherapy (RT) is slower. Although postoperative RT is recommended for most patients after breast-conserving surgery and, depending on risk…
This case report discusses a diagnosis of optic nerve melanocytoma in a woman aged 55 years who presented with progressive painless vision loss over a 7-month period.
This case report discusses a diagnosis of bilateral mumps-associated retinitis in a young male aged 16 years who had not received the mumps vaccine.
This case report describes a diagnosis of retinal vasculitis associated with Castleman disease in a man who presented with 6 months of progressive floaters bilaterally and no change in visual acuity.
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