This JAMA Guide to Statistics and Methods article discusses clinical trials using factorial designs in which participants receive several randomized interventions simultaneously to allow efficient evaluation of multiple therapies and their combinations.
This Surgical Innovation describes a new method to repair large or recurrent paraesophageal hernias.
Importance Integration of molecular biomarker information into systemic therapy has become standard practice in breast cancer care. However, its implementation in guiding radiotherapy (RT) is slower. Although postoperative RT is recommended for most patients after breast-conserving surgery and, depending on risk…
This case report discusses a diagnosis of optic nerve melanocytoma in a woman aged 55 years who presented with progressive painless vision loss over a 7-month period.
This case report discusses a diagnosis of bilateral mumps-associated retinitis in a young male aged 16 years who had not received the mumps vaccine.
This case report describes a diagnosis of retinal vasculitis associated with Castleman disease in a man who presented with 6 months of progressive floaters bilaterally and no change in visual acuity.
A 56-year-old woman presents with fever, headache, nausea, and vomiting. Computed tomography scan of the head shows multiple coarse, dystrophic calcifications, and she reports floaters with normal vision. What would you do next?
Importance Health information technology, such as electronic health records (EHRs), has been widely adopted, yet accessing and exchanging data in the fragmented US health care system remains challenging. To unlock the potential of EHR data to improve patient health, public health,…
A man aged 61 years presented with chronic progressive weakness and gait dysfunction over a 4-year period. He had Ashkenazi Jewish ancestry and a history of memory loss, inappropriate laughter, dysarthria, and hypertension. Examination revealed impaired recall, extremity spasticity, distal…
The US Food and Drug Administration has approved cannabis-derived medications for several indications. In this episode, family practitioner Randy Easterling, MD, highlights the current regulatory status of FDA-approved cannabis-derived medications and their approved uses.
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