Autophagy in Stress-Induced Neuropsychiatric Disorders and Depression
This article discusses how autophagic mechanisms mediate neurobiological and behavioral changes in stress-induced neuropsychiatric disorders and depression.
ABMS Lifelong Learning CME Activity
Therapeutic Use of Cannabis and Cannabinoids – A Review
Approximately 27% of adults in the US and Canada report having ever used cannabis for medical purposes. An estimated 10.5% of the US population reports using cannabidiol (CBD), a chemical compound extracted from cannabis that does not have psychoactive…
A Contemporary Look at the Landscape of Treatment of Tricuspid Regurgitation – A Review
Importance Untreated severe tricuspid regurgitation carries a poor prognosis. We aim to provide a contemporary review of the anatomy, clinical manifestations, and diagnostic and management strategies, including medical, surgical and transcatheter options. By synthesizing current knowledge, this review seeks to equip…
Standardization of Lesion Classification and Assessment by Investigators in Clinical Trials for Hidradenitis Suppurativa – A Consensus Exercise Using a Modified Delphi Approach
Importance Accurate classification and reliability in assessment for lesions of hidradenitis suppurativa (HS) by investigators is critical to the determination of responder status and to overall data quality in clinical trials. Objective To establish consensus-based morphological definitions of HS lesions and guidance…
Hereditary Leukonychia Associated With GJA1 Mutation
This case report describes a woman in her 30s with porcelain-white discoloration of all nails, which persisted under pressure, and a GJA1 mutation.
Ethics Talk: Lessons From Disability Ethics About Ageism
This activity is comprised of five multiple-choice questions based on the content of an AMA Journal of Ethics podcast about key ideas from disability ethics that can inform our thinking about age-related biases and how medicalizing aging affects our health,…
How Old Are You, Actuarily?
Advances in epigenetic age estimation are now applied in actuarial science to make risk assessment more precise. But such health insurance underwriting practices pose ethical and legal questions about discrimination, privacy, and equity in biological data use. Legal adaptations, such…
What Does It Mean for a Patient to “Look Older Than Their Stated Age”?
Documenting one’s assessment of a patient’s physical appearance during a clinical encounter is regarded as a key element in a clinician’s overall judgment of a patient’s health. This article considers ethically and clinically relevant uses and misuses of such appraisals…
What Are the Most Ethically Salient Implications of Epigenetic Age Testing?
This commentary on a case considers how clinicians should help patients interpret results of tests that might be personally meaningful but not clinically actionable. Tests of biological age, for example, can easily lead to patient misunderstandings that can increase risks…
World Health Organization Guideline on the Use and Indications of Glucagon-Like Peptide-1 Therapies for the Treatment of Obesity in Adults
Importance Obesity is a chronic, relapsing disease affecting over 1 billion people worldwide, driving substantial morbidity, mortality, and economic burden. Glucagon-like peptide-1 therapies (GLP-1 therapies) provide clinically meaningful weight loss and broad metabolic benefits. In response to Member State requests, the…
