Importance Emerging evidence suggests that progression independent of relapse activity (PIRA) is a substantial contributor to long-term disability accumulation in relapsing-remitting multiple sclerosis (RRMS). To date, there is no uniform agreed-upon definition of PIRA, limiting the comparability of published studies. Objective To…
A 6-year-old child presented with headache for 1 month and seizures followed by altered consciousness for 1 day. He had new-onset daily occipital headache for 1 month of mild to moderate severity and pulsating character. What is your diagnosis?
Importance There has been great enthusiasm for the emerging technology of molecular-based tests to detect and quantify tumor DNA circulating in the bloodstream, colloquially known as a liquid biopsy. However, less attention has been given to how their clinical utility depends…
Importance Cancer screening is often promoted as a means to save lives. The question of whether cancer screening truly saves lives is becoming increasingly relevant given the growing enthusiasm for multicancer detection blood tests (ie, liquid biopsies). It is possible in…
This case report describes a patient in their 40s with a history of end-stage kidney disease secondary to hypertension and diabetes who presented with fatigue, cough, weakness, and dyspnea on exertion and was subsequently diagnosed with acute disseminated cryptococcal infection.
This case report describes a patient in their 60s who developed apparent abnormal Q waves and severe hypomagnesemia while receiving chemotherapy for metastatic rectal carcinoma.
This case report describes a man in his 30s who presented to the emergency department with a sudden onset of distal extremity weakness after waking up 10 hours prior.
This case report describes a patient in their 40s with no history of cardiovascular disease who presented to the emergency department with chest pain accompanied by sweating.
Importance When the US Food and Drug Administration (FDA) approves a drug or medical device on the basis of limited clinical evidence, the Centers for Medicare & Medicaid Services (CMS) must decide whether the therapy is “reasonable and necessary” for coverage…
This case report presents the ECG findings of a patient in their 40s with post-tubercular bronchiectasis who presented with acute exacerbation of dyspnea and no chest pain.
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