Importance Neurological examinations traditionally rely on visual analysis of physical clinical signs, such as tremor, ataxia, or nystagmus. Contemporary score-based assessments aim to standardize and quantify these observations, but these tools suffer from clinimetric limitations and often fail to capture subtle…
Importance Nearly 5% of adults have the precursor malignant condition monoclonal gammopathy of unknown significance (MGUS). Management centers on differentiating MGUS from more serious conditions to determine additional diagnostic testing, monitoring, and potential therapy. Observations MGUS is defined by the absence of…
This Guide to Statistics and Methods provides an overview of platform trials, describes the characteristics that make them more efficient for evidence generation, and discusses their limitations.
This Teachable Moment describes an 87-year-old man who underwent fatal complications from the use of benzocaine spray for nasopharyngeal anesthesia before the insertion of a nasogastric tube.
This Surgical Innovation discusses the use of sonolucent materials in cranial reconstruction to allow for ultrasonographic imaging following cranial neurosurgery.
This case report describes an otherwise healthy 30-year-old man who presented with a sudden onset, rapidly progressive, and painful skin eruption accompanied by fever lasting for 1 week.
Importance Out-of-hospital cardiac arrest incidence in apparently healthy adults younger than 40 years ranges from 4 to 14 per 100 000 person-years worldwide. Of an estimated 350 000 to 450 000 total annual out-of-hospital cardiac arrests in the US, approximately 10% survive. Observations Among young…
Importance Since 2003, the Children’s Oncology Group (COG) has developed and disseminated the Long-Term Follow-Up Guidelines for Survivors of Childhood, Adolescent, and Young Adult Cancers. These guidelines have benchmarked the standard of care for long-term survivors of childhood cancer in North America…
This JAMA Insights discusses the increased risk of coccidioidomycosis due to climate change and the importance of clinicians, patients, and health systems being educated about the disease to ensure accurate identification and optimal care for patients.
This case report describes a diagnosis of vernal keratoconjunctivitis in a man aged 35 years who presented with redness and itching of both eyes since age 8 years.
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