Importance Evidence-based treatment decisions for advanced gastroenteropancreatic neuroendocrine neoplasms (GEP-NENs) require individualized patient-centered decision-making that accounts for patient and cancer characteristics. Objective To create an accessible guidance document to educate clinicians and patients on biomarkers informing prognosis and treatment in unresectable or…
A child aged 4 years presented with a 3-day history of worsening redness, pain, and swelling over the left lower eyelid and nose. Visual acuity was normal, and systemic examination revealed cervical lymphadenopathy and hepatosplenomegaly. The patient showed no improvement…
This Teachable Moment discusses a woman in her 60s with hypertension, hyperlipidemia, coronary artery disease, and smoking history who presented with bilateral, aching leg pain triggered by walking and relieved by rest.
This JAMA Insights in the Women’s Health series discusses the first over-the-counter progestin-only oral contraceptive available in the US, including its effectiveness, mechanism of action, and accessibility.
This article discusses the use of intraoperative autonomic neural blockade as a technique to manage postoperative visceral pain and symptoms of postoperative nausea and vomiting in minimally invasive surgery.
A man in his 50s with a 10-year history of Crohn disease had intermittent bowel obstructions leading to total proctocolectomy and ileostomy, and 5 weeks after surgery he developed a painful, erosive lesion around his stoma on the anterior abdominal…
Importance Blood transfusions are commonly administered to patients with acute brain injury. The optimal hemoglobin transfusion threshold is uncertain in this patient population. Objective To assess the impact on neurological outcome of 2 different hemoglobin thresholds to guide red blood cell transfusions…
This case report describes a diagnosis of ventricular septal rupture in a patient in his 70s after ST-segment elevation myocardial infarction (STEMI) due to right coronary artery occlusion.
A 65-year-old woman presented with a 6-month history of postmenopausal vaginal bleeding, and endometrial biopsy showed grade 2 endometrioid adenocarcinoma. What would you do next?
A patient in their mid-30s presented with pain and swelling involving the bridge of their nose. What is your diagnosis?
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