Importance The ongoing opioid-related overdose crisis in the US is increasingly affecting adolescents and is exacerbated by the widespread availability of illicitly manufactured fentanyl. Adolescents face significant gaps in care for prevention and treatment of opioid use and opioid-related harms. Regulatory…
This JAMA Insights discusses cesarean delivery on maternal request, including the need for counseling regarding maternal and infant risks, composite outcomes, and patient autonomy.
Importance Large language models (LLMs), a rapidly advancing domain of artificial intelligence (AI), are poised to transform administrative, clinical, and research paradigms. Although adoption across medicine has accelerated, otolaryngology represents only a fraction of this progress compared with other specialties. This…
This case report describes an incidence of corneal melt in a patient with a history of corneal insert implantation 26 years prior due to myopia.
This case report describes large areas of erythema on the face, chest, and back with relatively clear boundaries and swollen hands with scattered skin-colored papules and nodules.
Importance Recessive dystrophic epidermolysis bullosa (RDEB) is a rare monogenic blistering disorder with wide clinical heterogeneity, ranging from localized skin fragility to life-limiting systemic complications. Understanding genotype-phenotype correlations in COL7A1, the causative gene, is critical for clinical prognostication, genetic counseling, and the…
Importance The fallopian tube epithelium has been demonstrated to be an important source of tubo-ovarian carcinoma. Therefore, removal of the fallopian tubes during unrelated pelvic or abdominal surgery (opportunistic salpingectomy) can potentially lower future ovarian cancer risk. Objectives To assess current evidence…
This case report describes a patient in her early 60s who presented with substernal chest pain and diaphoresis.
This Clinical Insights outlines the clinical characteristics, diagnostic approach, and therapeutic strategies for managing scarring alopecias.
Despite legislative attention from Congress in the 1980s, diagnostic research on rare diseases is not lucrative enough to garner sufficient private funding. The Undiagnosed Diseases Network supports diagnostic research and intervention innovation for patients with undiagnosed or rare conditions. This…
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