Importance The safety and efficacy of intravenous thrombolytics beyond 4.5 hours after ischemic stroke onset remain inadequately studied. Objective To evaluate the safety and efficacy of intravenous alteplase administered 4.5 to 24 hours after stroke onset in patients with salvageable brain tissue,…
Importance The incidence of stroke, heart failure, dementia, many cancers, coronary artery disease, and physical disability rise exponentially with age. Geroscience is a relatively new discipline that aims to define and modify aging-related biologic pathways, slow age-related disability, prevent age-related diseases,…
This case report describes a 61-year-old man with alcohol use disorder who presented with altered consciousness and vision loss after ceasing alcohol consumption.
This Teachable Moment discusses the importance of recognizing the clinical clue of moth-eaten alopecia for secondary syphilis.
Importance Prostatitis is defined as infection, inflammation, or pain of the prostate gland and affects approximately 9.3% of men in their lifetime. Observations Acute bacterial prostatitis consists of a urinary tract infection (UTI) that includes infection of the prostate, typically associated with…
A 34-year-old patient with a family history of stroke had right-sided headache, left upper extremity hemiparesis, and left hand numbness; magnetic resonance angiography showed bilateral narrowing of the terminal portion of the intracranial carotid arteries, more severe on the right….
A man in his 60s with end-stage kidney failure presented with an acute eruption of painful rashes. What is your diagnosis?
Importance Dalbavancin is a long-acting intravenous lipoglycopeptide that may be effective for treatment of complicated Staphylococcus aureus bacteremia without requiring long-term intravenous access. Objective To evaluate the efficacy and safety of dalbavancin vs standard therapy for completion of treatment of complicated S aureus bacteremia. Design, Setting,…
This JAMA Insights discusses transmission, clinical presentation, and diagnosis of measles and emphasizes the importance of vaccination to protect those at highest risk for complications from measles, including young children and pregnant individuals.
A woman in her early 50s presented with a neck mass, incidentally discovered during evaluation of recurrent headaches. What is your diagnosis?
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