Importance The treatment of older adults with chemotherapy for early-stage breast cancer involves a complex decision-making process that weighs the competing risks of disease recurrence against the potential harms of treatment. While older adults continue to be underrepresented in therapeutic…
This case report of a patient aged 37 years with asymptomatic bilateral drusen discusses how adaptive optics transscleral flood illumination imaging enabled in vivo has the potential to detect subtle retinal pigment epithelial (RPE) changes in patients with drusen.
A 51-year-old woman presented with a 2-month progressively enlarging right nasal lesion and 1 week of painful oral lesions limiting her oral intake. She also noted painful, erythematous nodules on her arms and hands. What is your diagnosis?
Importance Respiratory syncytial virus (RSV) is a leading cause of acute respiratory tract infection and a contributor to morbidity and mortality. Objective To synthesize evidence from recent randomized clinical trials and observational studies reporting on the effectiveness and safety of…
Importance Alopecia areata (AA) is an autoimmune hair loss disorder that affects more than 7 million people in the US. Before US Food and Drug Administration–approved trials of Janus kinase inhibitors, numerous treatments had been explored, with variable efficacy and…
This case report discusses a diagnosis of Carney complex type 1 after genetic testing of a male patient aged 36 years with multiple atrial myxomas, bilateral testicular calcification, and a history of recurrent skin masses since childhood.
This JAMA Insights discusses suggested language for clinicians to use when communicating with families about brain death evaluation and determination.
Importance Influenza continues to cause significant mortality and morbidity in the US. Seasonal influenza vaccines reduce the severity of disease and prevent hospitalizations and death, especially among individuals at high risk. Objective To identify and summarize the most recently published…
Importance SARS-CoV-2 remains a substantial cause of respiratory illness, morbidity, and mortality. Evidence to date has demonstrated that COVID-19 vaccines reduce the risk of severe disease, including hospitalization and death. Objective This systematic review identifies and summarizes newly published studies…
Importance Obstructive sleep apnea (OSA) affects nearly 1 billion adults worldwide and is independently associated with cardiovascular disease, stroke, and increased mortality. While continuous positive airway pressure (CPAP) remains the criterion standard treatment, adherence rates of only 30% to 60%…
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