Importance Smoking is the strongest modifiable risk factor for peripheral arterial disease (PAD), yet evidence on how postdiagnosis smoking behavior changes affect clinical outcomes remains limited. Objective To evaluate the association among smoking cessation, reduction, and continuation after PAD diagnosis…
Importance Black women are disproportionately susceptible to developing heart failure and display more severe morbidity and mortality compared with White women. Factors contributing to excess heart failure risk among Black women remain incompletely understood. Objective To characterize the associations of…
Importance Evidence on the association of excess adiposity with colorectal cancer (CRC) prognosis is conflicting, with some studies reporting better survival in patients with elevated body mass index (BMI)—often referred to as the obesity paradox. Objective To investigate to what…
A 54-year-old woman presents with subacute exertional dyspnea after heavy lifting and a history of chronic repetitive upper-limb strain from caregiving. What would you do next?
This JAMA Insights discusses various aspects of primary aldosteronism, such as its epidemiology, diagnosis and screening, and treatment, including effective medication management.
A woman in her 50s with type 2 diabetes presented with hyperpigmented plaques on her abdomen. Physical examination revealed symmetric, hyperkeratotic, verrucous plaques with thick, brownish, firmly adhered crusts. What is your diagnosis?
Importance Blood-based biomarkers (BBM) provide minimally invasive, scalable, lower-cost tools for identifying neurodegenerative diseases, but prospective data on their clinical validity in memory clinic settings are limited. Objective To evaluate how a tailored plasma BBM panel (phosphorylated tau 181 [pTau181],…
Importance The role of chemokine C-C motif ligand 5 (CCL5) in respiratory viral infections remains controversial; although essential for viral clearance, it is also implicated in pathogenic hyperinflammation. Objective To quantify associations between CCL5 levels and unfavorable disease progression and…
Importance Obesity disproportionately affects low- and middle-income countries, where access to structured, scalable treatment remains limited. Objective To evaluate whether a hybrid-format, intensive lifestyle modification program combined with usual medical care promotes a minimum weight loss of 5% in adults…
Importance Intravenous thrombolysis (IVT) is an established therapy for acute ischemic stroke when administered within 4.5 hours of symptom onset. However, many patients present beyond this window or with unknown onset, and recent randomized clinical trials (RCTs) have evaluated whether…
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