Crossed Clonus Response
This case report describes a novel crossed clonus response in a 48-year-old man with compressive cervical myelopathy.
JAMA Neurology
Alzheimer Disease as a Clinical-Biological Construct—An International Working Group Recommendation
Importance Since 2018, a movement has emerged to define Alzheimer disease (AD) as a purely biological entity based on biomarker findings. The recent revision of the Alzheimer’s Association (AA) criteria for AD furthers this direction. However, concerns about a purely biological…
Clinical Presentation, Investigation Findings, and Outcomes of IgG4-Related Pachymeningitis – A Systematic Review
Importance Immunoglobulin G4 (IgG4)–related disease is an increasingly recognized fibroinflammatory condition that can involve multiple organs, including the pachymeninges. The understanding of IgG4-related pachymeningitis (IgG4-RP) remains limited because of its rarity and the predominance of knowledge derived from case reports and…
Vertebral Web and Embolic Stroke
This case report describes a female individual in her 30s with headache and vertigo; examination revealed acute embolic infarcts and a lesion on the vertebral artery.
Current and Future Roles of Chimeric Antigen Receptor T-Cell Therapy in Neurology – A Review
Importance Advancements in molecular engineering have facilitated the creation of engineered T cells that express synthetic receptors, termed chimeric antigen receptors (CARs). This is promising not only in cancer treatment but also in addressing a spectrum of other conditions. This review provides a…
Spinal Cerebrospinal Fluid Leak Mimicking a Cerebellopontine Angle Tumor
This case report describes a patient ís experience after seeking a second opinion regarding a brain tumor.
Steroid-Responsive Myorhythmia in Pectoralis Muscles
This case report describes a patient experiencing involuntary contractions in his right pectoralis muscles with anti-Tr antibodies in his serum, which is characteristic of myorhythmia.
Lesioning the BrainóFrom Serendipity to Science
This case report describes use of high-intensity focused ultrasound as a method to create spatially precise thermal lesions in the brain without a craniotomy.
Parkinsonism Following Chimeric Antigen Receptor T Cell Therapy
This case report describes a 67-year-old woman who had received adoptive immunotherapy with chimeric antigen receptor T cells for multiple myeloma and was experiencing parkinsonism-like symptoms.
Endovascular Stroke Thrombectomy for Patients With Large Ischemic Core – A Review
Importance Recently, 6 randomized clinical trials—RESCUE-Japan-LIMIT (Recovery by Endovascular Salvage for Cerebral Ultra-Acute Embolism—Japan Large Ischemic Core Trial), ANGEL-ASPECT (Trial of Endovascular Therapy for Acute Ischemic Stroke With Large Infarct), SELECT2 (Trial of Endovascular Thrombectomy for Large Ischemic Strokes), TESLA (Thrombectomy…
