A Mysterious ST Elevation
This case report describes the electrocardiogram of a patient in their 70s with palpitations, fatigue, and dyspnea taking a combination of an immune checkpoint inhibitor and chemotherapy for lung cancer.
JAMA Internal Medicine
Evaluation of Hypercortisolism in Mild Autonomous Cortisol Secretion
This Teachable Moment describes a woman in her early 50s with obesity, hypertension, and type 2 diabetes who presented to the endocrine clinic for evaluation of an incidental left adrenal nodule.
Projected Lifetime Cancer Risks From Current Computed Tomography Imaging
Importance Approximately 93 million computed tomography (CT) examinations are performed on 62 million patients annually in the United States, and ionizing radiation from CT is a known carcinogen. Objective To project the number of future lifetime cancers in the US population associated…
Semaglutide vs Tirzepatide for Weight Loss in Adults With Overweight or Obesity
Importance Although tirzepatide and semaglutide were shown to reduce weight in randomized clinical trials, data from head-to-head comparisons in populations with overweight or obesity are not yet available. Objective To compare on-treatment weight loss and rates of gastrointestinal adverse events (AEs) among…
Targeting MASLD and MASH in the US Hispanic/Latino Population – A Review
Importance The prevalence of metabolic dysfunction–associated steatotic liver disease (MASLD) in the US is highest among Hispanic/Latino individuals. Their risk of developing metabolic dysfunction–associated steatohepatitis (MASH) with fibrosis, cirrhosis with progression to hepatocellular carcinoma and need for liver transplant, and death…
The Rise in Early-Onset Cancer in the US Population—More Apparent Than Real
Importance Rising rates of early-onset cancer have generated substantial media coverage and public concern. In response, early-onset cancer has become a federal research priority, and clinical guidelines have shifted to recommend earlier screening for some cancers. Yet, it remains unclear whether…
A Person-Centered Approach to Supplemental Oxygen Therapy in the Outpatient Setting – A Review
Importance Approximately 1.5 million adults in the US use supplemental oxygen annually in the outpatient setting. However, many do not receive delivery systems that adequately meet their needs, and few receive education about devices or how to maintain independence. This Review…
An Ominous Electrocardiographic Pattern in Undefined Syncope
This case report describes a patient in his late 60s who presented to the emergency department with a 3-month history of recurrent spontaneous chest tightness, palpitations, and syncope.
Nonhormonal Treatment of Menopausal Vasomotor Symptoms
This work discusses nonhormonal treatment of menopausal vasomotor symptoms.
Landscape of Emergency Medicaid and Health Care Coverage for Undocumented Immigrants in the US
Importance Undocumented immigrants represent a disproportionate share of uninsured individuals in the US, owing to federal restrictions that limit access to affordable health care coverage. Emergency Medicaid (EM) and other state-sponsored programs offer mechanisms for receiving necessary medical care, but their…
