This clinical insight discusses the diagnosis and management of adverse effects of antiamyloid therapies and what medications require consideration or avoidance.
This Guide to Statistics and Methods provides an overview of the covariate-constrained randomization design, which can achieve improved control over large imbalances across study arms at the cluster level over simpler methods of randomization.
This Clinical Insights describes the process for initiating feminizing gender-affirmative hormone therapy for transgender women or nonbinary people.
This case report describes a patient in their 30s with hypertension, anxiety, depression, chronic tremulousness, nausea, vomiting, headache, and mental fog.
This case report describes a man in his 60s who presented with a 3-day history of low-grade, intermittent fever, myalgia, and headache, along with episodes of blurred vision and recurrent syncope.
This Clinical Insight reviews the lifestyle factors important for patients receiving glucagon-like peptide-1 and dual receptor agonists to manage weight.
Importance Nearly 5% of adults have the precursor malignant condition monoclonal gammopathy of unknown significance (MGUS). Management centers on differentiating MGUS from more serious conditions to determine additional diagnostic testing, monitoring, and potential therapy. Observations MGUS is defined by the absence of…
This Teachable Moment describes an 87-year-old man who underwent fatal complications from the use of benzocaine spray for nasopharyngeal anesthesia before the insertion of a nasogastric tube.
This Guide to Statistics and Methods discusses target trial emulation, including why to use it, limitations of the method, and how to interpret target trial emulation findings.
This Teachable Moment discusses initiation, optimization, and long-term use of buprenorphine in man with an opioid use disorder.
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