Glucagon-like peptide-1 (GLP-1) has emerged as a key regulator in metabolic health, with profound implications for diabetes management, weight loss, and cardiovascular protection. The 135th Annual Shattuck Lecture explores the discovery, physiological role, and therapeutic applications of GLP-1 receptor agonists…
Surgical research involving patients who are incarcerated is fraught with ethical, logistical, and practical questions. This article first considers important moments in the history of research with people who are incarcerated and suggests how they have contributed to evolution in…
Safety-net hospitals care for patients who are incarcerated and are key environments in which surgical trainees learn to wield their professional autonomy. This article explores ethical questions raised by surgical trainees’ participation in carceral care and canvasses possible responses to…
This activity is comprised of five multiple-choice questions based on the CJ featured guest is Cynthia Chandler, JD, director of the Bay Area Legal Incubator in Oakland, California; and Anthony Loria, MD, a research resident at the University of Rochester…
Importance Direct immunofluorescence (DIF) testing has been an important ancillary tool for the diagnosis of various inflammatory mucocutaneous conditions for more than 50 years. Current DIF test panels are based on historical clinical descriptions; few studies have rigorously addressed preanalytical, analytical,…
This JAMA Clinical Guidelines Synopsis summarizes the 2022-2023 recommendations on evaluation and management of chronic venous disease of the lower extremities from the Society for Vascular Surgery, American Venous Forum, and American Vein and Lymphatic Society.
This case report describes a woman in her 60s with smoking history, chronic productive cough, weight loss, and asymptomatic thickening of the palmar skin.
Importance Despite recent declines in breast cancer mortality rates, substantial disparities persist among race and ethnicity groups. Genomic assays are crucial for understanding the biological characteristics of tumors, providing valuable insights into prognosis and treatment response. Their integration into personalized clinical…
Importance Approximately 1.5 million adults in the US use supplemental oxygen annually in the outpatient setting. However, many do not receive delivery systems that adequately meet their needs, and few receive education about devices or how to maintain independence. This Review…
Importance Staphylococcus aureus, a gram-positive bacterium, is the leading cause of death from bacteremia worldwide, with a case fatality rate of 15% to 30% and an estimated 300 000 deaths per year. Observations Staphylococcus aureus bacteremia causes metastatic infection in more than one-third of…
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