This JAMA Guide to Statistics and Methods explains tipping point analysis, which assesses how a range of hypothetical patterns in missing outcome data in a randomized clinical trial (RCT) would affect the study’s conclusions, and examines its use in an…
Importance Adrenal insufficiency is a syndrome of cortisol deficiency and is categorized as primary, secondary, or glucocorticoid induced. Although primary and secondary adrenal insufficiency are rare, affecting less than 279 per 1 million individuals, glucocorticoid-induced adrenal insufficiency is common. Observations Primary adrenal…
Importance The US Food and Drug Administration (FDA) and National Institutes of Health (NIH) share a mutual interest in facilitating efficient, well-designed clinical studies of drugs, devices, and biological products. Recent advances in science and technology, as well as innovative approaches…
Importance Increasing child and adolescent use of social media, video games, and mobile phones has raised concerns about potential links to youth mental health problems. Prior research has largely focused on total screen time rather than longitudinal addictive use trajectories. Objectives To…
A 50-year-old woman presented to the dermatology department with a 10-year history of recurrent plaque outbreaks between her toes and a history of Bowen disease in the anus that had been treated with excision and skin grafting. What is your…
A man in his 60s with a history of hypertension, hyperlipidemia, and coronary artery disease presented with symmetrical diffuse, reticulated telangiectatic macules covering the legs and forearms. Dermoscopy revealed prominent fine telangiectasias, which was blanchable on pressure. What is your…
Importance Head and neck squamous cell cancer (HNSCC) is associated with a higher positive margin rate compared with most other cancers in surgical oncology. This rate has remained stagnant over the past 3 decades. Fluorescence-guided surgery (FGS) is a promising tool…
Importance Defining on-treatment remission in plaque psoriasis is important for benchmarking patient responses to therapies. This also helps to facilitate shared understanding, align treatment expectations, and enable more effective psoriasis management. Objective To establish a consensus-based definition of on-treatment remission for plaque…
This JAMA Insights proposes solutions to help reduce the risk of heat-related illnesses among workers.
This case report describes bilateral subconjunctival petechial hemorrhages in a man aged 28 years who tested positive for dengue virus infection.
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